Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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3 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 4.3.2.1

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Active criteria 1
EC Number: 4.3.2.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_5039 imidazole glycerol phosphate synthase, HisF subunit hisF AlphaFold + ColabFold
4.3.2.10
GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.997 No Hit 0.0% —
2 VK055_3227 argininosuccinate lyase argH AlphaFold + ColabFold
4.3.2.1
GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. +14 total
0.592 Hit 70.0% 9.84e-18
3 VK055_5041 imidazole glycerol phosphate synthase, glutamineamidotransferase subunit hisH AlphaFold + ColabFold
4.3.2.10 3.5.1.2
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.516 No Hit 0.0% —
Page 1 of 1 · 3 total proteins