Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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6 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 5.4.99.-

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Active criteria 1
EC Number: 5.4.99.- ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_1319 23S rRNA pseudouridine 2457 synthase AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.598 No Hit 0.0% —
2 VK055_1188 23S rRNA pseudouridine 2605 synthase AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.538 No Hit 0.0% —
3 VK055_3064 23S rRNA pseudouridine 2604 synthase AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.483 No Hit 0.0% —
4 VK055_4583 23S rRNA pseudouridine synthase AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
0.433 Hit 43.4% 4.06e-06
5 VK055_2517 23S rRNA and tRNA pseudouridine synthase yabO AlphaFold + ColabFold
5.4.99.-
GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.318 Hit 48.1% 6.54e-12
6 VK055_4905 16S rRNA pseudouridine 516 synthase rsuA AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +58 total
0.251 No Hit 0.0% —
Page 1 of 1 · 6 total proteins