Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2601 VK055_1924 (2,3-dihydroxybenzoyl)adenylate synthase entE AlphaFold + ColabFold –
GO:0008668Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
0.554 Hit 34.0% 2.81e-16
2602 VK055_0064 MAPEG family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.554 No Hit 0.0% —
2603 VK055_4280 major Facilitator Superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.553 No Hit 0.0% —
2604 VK055_3689 pimelyl-[acyl-carrier protein] methyl ester esterase bioH Experimental + ColabFold –
GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
0.553 Hit 30.2% 2.30e-06
2605 VK055_3589 tetratricopeptide repeat family protein AlphaFold + ColabFold –
GO:0030244The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0005515Binding to a protein.
0.553 Hit 42.6% 4.00e-06
2606 VK055_1348 liporeleasing system, transmembrane protein LolE lolE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0044874A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. +14 total
0.553 No Hit 0.0% —
2607 VK055_0501 pyridoxamine 5'-phosphate oxidase pdxH AlphaFold + ColabFold
1.4.3.5
GO:0004733Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + H2O2. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + H2O2. GO:0016638Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +14 total
0.553 Hit 47.4% 2.38e-42
2608 VK055_5180 hypothetical protein AlphaFold + ColabFold – – 0.552 No Hit 0.0% —
2609 VK055_3730 argD AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +25 total
0.552 Hit 38.6% 1.06e-07
2610 VK055_3332 ATP synthase F0, B subunit atpF AlphaFold + ColabFold –
GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0015078Enables the transfer of a proton from one side of a membrane to the other. GO:0045263OBSOLETE. All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. +58 total
0.552 No Hit 0.0% —
2611 VK055_1627 hypothetical protein AlphaFold + ColabFold – – 0.552 No Hit 0.0% —
2612 VK055_1388 ribosomal-protein-S5-alanine N-acetyltransferase rimJ AlphaFold + ColabFold
2.3.1.267
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008999Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].
0.552 No Hit 0.0% —
2613 VK055_0021 hypothetical protein AlphaFold + ColabFold – – 0.552 No Hit 0.0% —
2614 VK055_5052 DD-carboxypeptidase, penicillin-binding protein 6b AlphaFold + ColabFold
3.4.16.4
GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0009002Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. +58 total
0.551 No Hit 0.0% —
2615 VK055_3031 alanine racemase alr2 AlphaFold + ColabFold
5.1.1.1
GO:0006522OBSOLETE. The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008784Catalysis of the reaction: L-alanine = D-alanine. +47 total
0.551 No Hit 0.0% —
2616 VK055_0806 hypothetical protein AlphaFold + ColabFold – – 0.551 No Hit 0.0% —
2617 VK055_4335 precorrin-6x reductase cobK AlphaFold + ColabFold –
GO:0016994Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.55 No Hit 0.0% —
2618 VK055_4271 putative aspartate/glutamate racemase AlphaFold + ColabFold –
GO:0047661Catalysis of the reaction: an L-amino acid = a D-amino acid. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +14 total
0.55 No Hit 0.0% —
2619 VK055_4048 tonB-system energizer ExbB exbB AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.55 No Hit 0.0% —
2620 VK055_2568 hypothetical protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0033194Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
0.55 No Hit 0.0% —
2621 VK055_1349 liporeleasing system, ATP-binding protein lolD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0044873A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. +14 total
0.55 Hit 54.1% 5.74e-06
2622 VK055_0962 3-carboxy-cis,cis-muconate cycloisomerase pcaB AlphaFold + ColabFold
5.5.1.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. +14 total
0.55 Hit 30.7% 1.03e-11
2623 VK055_3812 acetyl-CoA carboxylase, biotin carboxyl carrier protein accB AlphaFold + ColabFold –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
0.549 Hit 37.5% 3.10e-06
2624 VK055_3541 xylulokinase xylB2 AlphaFold + ColabFold
2.7.1.17
GO:0005997The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +58 total
0.549 Hit 31.4% 5.31e-07
2625 VK055_2858 hxlR-like helix-turn-helix family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.549 No Hit 0.0% —
Page of 204 · 5081 total proteins