Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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4645 / 5081 proteins Structure: AlphaFold

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Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
451 VK055_5140 cbl transcriptional activator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +14 total
No map 0.929 No Hit 0.0% —
452 VK055_4211 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.929 No Hit 0.0% —
453 VK055_3565 sulfatase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. +47 total
No map 0.929 No Hit 0.0% —
454 VK055_2714 flavin containing amine oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.929 No Hit 0.0% —
455 VK055_1650 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.929 No Hit 0.0% —
456 VK055_1384 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.929 No Hit 0.0% —
457 VK055_1050 dicarboxylate transport family protein AlphaFold DB model + ColabFold model – – No map 0.929 No Hit 0.0% —
458 VK055_0217 protein-(glutamine-N5) methyltransferase, release factor-specific prmC AlphaFold DB model + ColabFold model
2.1.1.297
GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. GO:0003676Binding to a nucleic acid. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. +36 total
No map 0.929 Hit 29.9% 2.32e-17
459 VK055_3667 pirin-like protein yhhW AlphaFold DB model + ColabFold model – – Mapped 1 0.928 Hit 31.8% 2.80e-07
460 VK055_3183 polysaccharide biosynthesis family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.928 No Hit 0.0% —
461 VK055_2506 thiamin/thiamine pyrophosphate ABC transporter, thiamin/thiamine pyrophospate-binding protein thiB AlphaFold DB model + ColabFold model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015888The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
No map 0.928 No Hit 0.0% —
462 VK055_1366 ptsG ptsG AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005355OBSOLETE. Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. +25 total
No map 0.928 No Hit 0.0% —
463 VK055_1197 tryptophan synthase, alpha subunit trpA AlphaFold DB model + ColabFold model –
GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0006568The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
Chokepoint 3 0.928 No Hit 0.0% —
464 VK055_0784 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.928 No Hit 0.0% —
465 VK055_5007 3-methyl-adenine DNA glycosylase II, inducible AlphaFold DB model + ColabFold model
3.2.2.21
GO:0003905Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +811 total
No map 0.927 No Hit 0.0% —
466 VK055_2323 ubiquinone oxidoreductase, Na(+)-translocating, E subunit nqrE AlphaFold DB model + ColabFold model
7.2.1.1
GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.927 No Hit 0.0% —
467 VK055_2001 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015858The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.927 No Hit 0.0% —
468 VK055_1608 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.927 No Hit 0.0% —
469 VK055_1139 murein peptide amidase A ycjI AlphaFold DB model + ColabFold model
3.4.17.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+. GO:0004181Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +69 total
No map 0.927 No Hit 0.0% —
470 VK055_4848 NADH:ubiquinone oxidoreductase, membrane subunitM nuoM AlphaFold DB model + ColabFold model –
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +47 total
No map 0.926 Hit 32.4% 2.87e-44
471 VK055_4333 cobalamin synthesis G family protein AlphaFold DB model + ColabFold model –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
No map 0.926 No Hit 0.0% —
472 VK055_2676 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.926 No Hit 0.0% —
473 VK055_2343 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.926 Hit 26.1% 5.07e-06
474 VK055_2296 dihydrolipoyl dehydrogenase lpdA AlphaFold DB model + ColabFold model
1.8.1.4
GO:0004148Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +47 total
Chokepoint 6 0.926 Hit 61.4% 1.12e-15
475 VK055_0470 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.926 No Hit 0.0% —
Page of 186 · 4645 total proteins