Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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155 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_04382 putative oxidoreductase Experimental + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.998 Hit 41.2% 3.87e-07
2 KP13_02441 Efflux pump membrane transporter OqxB oqxB Experimental + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
0.998 No Hit 0.0% —
3 KP13_03630 Acriflavine resistance protein B acrB Experimental + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042908The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
0.997 No Hit 0.0% —
4 KP13_01696 Lipopolysaccharide biosynthesis protein rffA rffA Experimental + ColabFold –
GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019180Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate.
0.997 No Hit 0.0% —
5 KP13_32248 Beta-lactamase SHV-12 Experimental + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.996 No Hit 0.0% —
6 KP13_31849 Beta-lactamase SHV 110 Experimental + ColabFold –
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.996 No Hit 0.0% —
7 KP13_06703 Carbepenem-hydrolyzing beta-lactamase KPC2 Experimental + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +25 total
0.994 No Hit 0.0% —
8 KP13_03591 UDP-2,3-diacylglucosamine hydrolase lpxH Experimental + ColabFold –
GO:0016462Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
0.994 No Hit 0.0% —
9 KP13_03540 putative iron-dependent peroxidase Experimental + ColabFold
1.11.1.-
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0004601Catalysis of the reaction: a reduced substrate + ROOH = an oxidized substrate + ROH + H2O. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.991 No Hit 0.0% —
10 KP13_00676 Maltodextrin phosphorylase malP Experimental + ColabFold
2.4.1.1
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008184Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. +47 total
0.984 Hit 49.6% 5.13e-69
11 KP13_03034 Transcriptional regulatory protein basR basR Experimental + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.981 No Hit 0.0% —
12 KP13_02040 1-deoxy-D-xylulose-5-phosphate synthase dxs Experimental + ColabFold –
GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008661Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2.
0.978 Hit 24.0% 8.85e-17
13 KP13_01349 Bifunctional protein birA birA Experimental + ColabFold
6.3.4.15
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). GO:0004077Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein]. +36 total
0.976 Hit 31.7% 4.92e-06
14 KP13_04571 hypothetical protein Experimental + ColabFold –
GO:0005254Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion.
0.975 No Hit 0.0% —
15 KP13_03495 Histone deacetylase superfamily protein Experimental + ColabFold
3.5.1.-
GO:0004407Removal of an acetyl group from a lysine residue in a histone. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +14 total
0.974 Hit 36.2% 2.04e-35
16 KP13_04387 hypothetical protein Experimental + ColabFold – – 0.97 No Hit 0.0% —
17 KP13_02920 Na(+)-translocating NADH-quinone reductase subunit F nqrF Experimental + ColabFold –
GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.966 Hit 26.5% 2.27e-08
18 KP13_00573 Primosomal protein N' priA Experimental + ColabFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003676Binding to a nucleic acid. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. +36 total
0.962 No Hit 0.0% —
19 KP13_05081 Acetolactate synthase, catabolic budB Experimental + ColabFold
2.2.1.6
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0034077The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3. +69 total
0.958 Hit 36.9% 1.74e-10
20 KP13_03232 RNA polymerase sigma-54 factor rpoN Experimental + ColabFold –
GO:0006352The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.954 No Hit 0.0% —
21 KP13_04211 Seryl-tRNA synthetase serS Experimental + ColabFold –
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.953 Hit 35.0% 1.17e-60
22 KP13_03794 UDP-glucose 6-dehydrogenase in cps region ugd Experimental + ColabFold
1.1.1.22
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.951 Hit 31.7% 4.92e-06
23 KP13_05153 Oxidoreductase Experimental + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.95 Hit 27.0% 2.53e-06
24 KP13_00160 Ferredoxin--NADP reductase fpr Experimental + ColabFold
1.18.1.2 1.19.1.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004324Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.943 No Hit 0.0% —
25 KP13_01136 EAL domain-containing protein Experimental + ColabFold –
GO:0009882The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
0.942 No Hit 0.0% —
Page of 7 · 155 total proteins