Bacterial genome

KpKP13

Curated analysis Druggability scores from a reviewed external import.

Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Source: Public Organism: Klebsiella pneumoniae Sequence length: 5,739,888 bp Strain: subsp. pneumoniae Kp13 Completion: Complete sequence
Proteins Metabolism
Add data Custom score EC tree BLAST
Export view
Proteins 5842
With 3D structure 5840
Annotated 4132
With pocket score 5816
Direct ligand hits 128

Top-ranked candidates

Composite score (0-100%) weighing druggability, ligand evidence, and five other independent signals.

How is this calculated?

FPocket druggability, P2Rank pocket support, ligand evidence type, selectivity/off-target screens, essentiality, conservation, structure, and metabolic context each contribute independently. Ligand counts are context, not a linear score multiplier - direct PDB ligand, measured ChEMBL activity, homolog-transferred evidence, and ZINC proposals are capped separately. Use the ligand-support ranking alongside this one when the raw count itself matters.

Export CSV
  1. #1 KP13_31849
    63% Moderate

    Beta-lactamase SHV 110

    High FPocket druggability 1P2Rank pocket supportExperimental PDB ligandMeasured ChEMBL activity+2

  2. #2 KP13_32248
    63% Moderate

    Beta-lactamase SHV-12

    High FPocket druggability 1P2Rank pocket supportExperimental PDB ligandMeasured ChEMBL activity+2

  3. #3 KP13_06703
    63% Moderate

    Carbepenem-hydrolyzing beta-lactamase KPC2

    High FPocket druggability 0.99P2Rank pocket supportExperimental PDB ligandMeasured ChEMBL activity+2

  4. #4 KP13_03591
    58% Moderate

    UDP-2,3-diacylglucosamine hydrolase

    High FPocket druggability 0.99P2Rank pocket supportExperimental PDB ligandZINC proposed compounds+2

  5. #5 KP13_01047
    58% Moderate

    putative phospholipid-binding lipoprotein mlaA

    High FPocket druggability 0.94P2Rank pocket supportExperimental PDB ligandZINC proposed compounds+2

Strong is at least 65% of the maximum weighted evidence; Moderate is 40-65%; Limited is below 40%. This ranking is only a first-pass triage. Create your own score →

No ligand evidence yet

Worth a fresh look

Same composite score, restricted to proteins with zero ligand records - promising candidates nobody has drugged yet, instead of the ones already best-studied.

  1. #1 KP13_31770
    43% Moderate

    intracellular growth attenuator protein IgaA

    High FPocket druggability 0.88P2Rank pocket supportNo similar human proteinEssential-gene similarity+2

  2. #2 KP13_00914
    40% Moderate

    hypothetical protein

    High FPocket druggability 1P2Rank pocket supportNo similar human proteinNo gut microbiome hit+1

  3. #3 KP13_05305
    40% Moderate

    Cytochrome c-type biogenesis protein ccmF

    High FPocket druggability 1P2Rank pocket supportNo similar human proteinEssential-gene similarity+2

  4. #4 KP13_03086
    40% Moderate

    F-type conjugal transfer protein TraE

    High FPocket druggability 1P2Rank pocket supportNo similar human proteinNo gut microbiome hit+1

  5. #5 KP13_02505
    40% Moderate

    Carbon starvation protein

    High FPocket druggability 1P2Rank pocket supportNo similar human proteinEssential-gene similarity+2

Ranked by the same non-chemical evidence as the main ranking: druggability, selectivity, essentiality, conservation, structure, and metabolic role. Once real ligand evidence appears for one of these, it will move to the main ranking instead.

Evidence available

Structural, functional, ligand, and metabolic evidence available for proteins in this genome.

3D structures 5840 proteins
  • Loaded experimental174
  • PDB xref proteins72
  • PDB xref entries258
  • AlphaFold DB models5192
  • ColabFold models5840
Functional annotation 4132 annotated proteins
  • EC1151
  • GO4132
Ligand evidence for this genome 128 direct hits 151153 total records · 2736 proteins
  • PDB co-crystal124
  • PDB via homologs18225
  • ChEMBL bioactive4
  • ChEMBL via homologs19400
  • ZINC proposed113400
CDS 5842 RNA features 110 Total features 5,973

Note: PDB and ChEMBL records on this protein are the strongest ligand evidence. Similar-protein records are inferred from related proteins and should be interpreted as transferred evidence. ChEMBL similar-protein records are capped at the top 100 per protein and ZINC at the top 50 candidates.

Downloads

Download source genome and annotation files.

Imported genome details

Properties imported from the source record.

Show imported genome details
Sequence length [bp] 5739888
Gene features 5973
Protein-coding features 5842
tRNA features 86
rRNA features 24
3D structures 5840
GC —