Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Human identity (%) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_01892 GMP reductase guaC AlphaFold + ColabFold –
GO:0009117The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003920Catalysis of the reaction: IMP + NADP+ + NH4 = GMP + 2 H+ + NADPH. +25 total
0.659 Hit 87.5% 2.28e-18
2 KP13_01352 Elongation factor Tu AlphaFold + ColabFold
3.6.5.3
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005525Binding to GTP, guanosine triphosphate. +58 total
0.781 Hit 81.2% 1.64e-09
3 KP13_00743 Elongation factor Tu tufA AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005525Binding to GTP, guanosine triphosphate. +14 total
0.781 Hit 81.2% 1.64e-09
4 KP13_00016 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG mnmG AlphaFold + ColabFold –
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0005515Binding to a protein. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +36 total
0.616 Hit 76.3% 1.92e-06
5 KP13_00846 NifU-like protein nifU AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.181 Hit 75.4% 2.18e-69
6 KP13_00494 60 kDa chaperonin groL AlphaFold + ColabFold
5.6.1.7
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. GO:0042026The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. +47 total
0.209 Hit 75.0% 5.59e-08
7 KP13_03332 Leucyl-tRNA synthetase leuS AlphaFold + ColabFold
6.1.1.4
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0006429The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +58 total
0.782 Hit 73.0% 9.06e-12
8 KP13_00025 ATP synthase subunit beta atpD AlphaFold + ColabFold
7.1.2.2
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0046034The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. GO:1902600The directed movement of a proton across a membrane. +69 total
0.523 Hit 71.5% 0.00e+00
9 KP13_31612 Peptide methionine sulfoxide reductase msrA msrA AlphaFold + ColabFold
1.8.4.11
GO:0008113Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033744Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol. +14 total
0.021 Hit 70.7% 3.01e-41
10 KP13_00845 Cysteine desulfurase iscS AlphaFold + ColabFold
2.8.1.7
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. +47 total
0.469 Hit 70.7% 1.30e-29
11 KP13_00362 Glucose-6-phosphate isomerase pgi AlphaFold + ColabFold
5.3.1.9
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0097367Binding to a carbohydrate derivative. +58 total
0.764 Hit 70.2% 0.00e+00
12 KP13_01375 Uroporphyrinogen decarboxylase hemE AlphaFold + ColabFold
4.1.1.37
GO:0004853Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. GO:0006779The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.095 Hit 70.2% 6.51e-21
13 KP13_00554 Argininosuccinate lyase argH AlphaFold + ColabFold
4.3.2.1
GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. +14 total
0.592 Hit 70.0% 9.84e-18
14 KP13_03310 Glutaminyl-tRNA synthetase glnS AlphaFold + ColabFold
6.1.1.18
GO:0006425The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +811 total
0.933 Hit 69.7% 2.17e-07
15 KP13_32247 Glyceraldehyde-3-phosphate dehydrogenase gapA AlphaFold + ColabFold
1.2.1.-
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. +36 total
0.502 Hit 69.7% 7.91e-128
16 KP13_03278 Succinate dehydrogenase iron-sulfur subunit sdhB AlphaFold + ColabFold
1.3.5.1
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +710 total
0.437 Hit 68.9% 1.16e-42
17 KP13_03274 Succinyl-CoA ligase [ADP-forming] subunit alpha sucD AlphaFold + ColabFold
6.2.1.5
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009361A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +36 total
0.867 Hit 68.7% 5.63e-64
18 KP13_01779 Methionine import ATP-binding protein metN 1 metN1 AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0033232Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). GO:0048473The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.434 Hit 67.6% 1.01e-07
19 KP13_04437 S-(hydroxymethyl)glutathione dehydrogenase AlphaFold + ColabFold
1.1.1.284
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006069OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. GO:0008270Binding to a zinc ion (Zn). +710 total
0.288 Hit 67.3% 4.95e-46
20 KP13_02179 Glycine dehydrogenase gcvP AlphaFold + ColabFold
1.4.4.2
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006544The chemical reactions and pathways involving glycine, aminoethanoic acid. +69 total
0.961 Hit 67.3% 2.72e-20
21 KP13_02736 alanine racemase domain-containing protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
0.873 Hit 66.7% 9.32e-06
22 KP13_01981 Chaperone protein dnaK dnaK AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051082Binding to an unfolded protein. GO:0140662Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. +25 total
0.425 Hit 65.9% 4.46e-54
23 KP13_32123 chaperone protein HtpG htpG AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051082Binding to an unfolded protein. +36 total
0.501 Hit 65.8% 2.21e-10
24 KP13_04919 3-oxoacyl-[acyl-carrier-protein] reductase fabG Experimental + ColabFold
1.1.1.100
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004316Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
0.42 Hit 65.6% 2.44e-06
25 KP13_05240 Methionine import ATP-binding protein MetN 1 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.497 Hit 64.9% 1.57e-07
Page of 234 · 5842 total proteins