Bacterial genome

NC_002516.2

Pseudomonas aeruginosa PAO1, complete genome

Source: Public Organism: Pseudomonas aeruginosa Sequence length: 6,264,404 bp Strain: PAO1 Completion: Complete genome
Proteins Add data Custom score EC tree BLAST
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Proteins 5572
With 3D structure 5565
Annotated 4466
With pocket score 5305

Top drug-target candidates

Ranked by the Druggability score computed from FPocket pockets (0–1). Higher values indicate more druggable binding sites.

  1. #1 PA0585 Druggability 0.99

    hypothetical protein

    Highly druggable · 0.99
  2. #2 PA1577 Druggability 0.99

    hypothetical protein

    Highly druggable · 0.987
  3. #3 PA0076 Druggability 0.99

    hypothetical protein

    Highly druggable · 0.986
  4. #4 PA2203 Druggability 0.99

    amino acid permease

    Highly druggable · 0.986
  5. #5 PA2048 Druggability 0.98

    hypothetical protein

    Highly druggable · 0.985

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Strongest ligand support

Proteins with ligands reported for the same protein are ranked first. Ligands inferred from similar proteins and proposed ZINC compounds are shown separately.

  1. #1 PA4406 126 direct

    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

    PDB co-crystal 34 ChEMBL bioactive 92 Via homologs 28 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  2. #2 PA3361 55 direct

    fucose-binding lectin PA-IIL

    PDB co-crystal 5 ChEMBL bioactive 50 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  3. #3 PA0019 48 direct

    peptide deformylase

    PDB co-crystal 3 ChEMBL bioactive 45 Via homologs 9 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  4. #4 PA1430 42 direct

    transcriptional regulator LasR

    PDB co-crystal 15 ChEMBL bioactive 27 Via homologs 34 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  5. #5 PA4110 32 direct

    beta-lactamase

    PDB co-crystal 13 ChEMBL bioactive 19 Via homologs 90 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher

PDB co-crystal ligands and ChEMBL bioactivity data reported for this exact protein are ranked first.

Evidence available

Computed analyses available for proteins in this genome.

3D structures 5565 proteins
  • Loaded experimental701
  • PDB xref proteins707
  • PDB xref entries2293
  • AlphaFold5425
  • ColabFold140
Functional annotation 4466 annotated proteins
  • EC1244
  • GO4466
Ligand evidence for this genome 864 direct hits 163581 total records · 2928 proteins
  • PDB co-crystal524
  • PDB via homologs18566
  • ChEMBL bioactive340
  • ChEMBL via homologs21299
  • ZINC proposed122852
CDS 5572 RNA features 106 Total features 5,697

Note: PDB and ChEMBL records on this protein are the strongest ligand evidence. Similar-protein records are inferred from related proteins and should be interpreted as transferred evidence. ChEMBL similar-protein records are capped at the top 100 per protein and ZINC at the top 50 candidates.

Downloads

Download source genome and annotation files.

Imported genome details

Properties imported from the source record.

Show imported genome details
Sequence length [bp] 6264404
Gene features 5697
Protein-coding features 5572
tRNA features 63
rRNA features 13
ncRNA features 29
tmRNA features 1