Protein profile

HT085_RS00015

polyphosphate kinase 1

Genome: NZ_AP023069.1

Gene: ppk E8M63_03535 TUM19854C_00030 ppk1 Structure source: AlphaFold
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Amino acids 685
Annotations 6
Features 28
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00015
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
ppk E8M63_03535 TUM19854C_00030 ppk1
Status
annotated
Amino acids
685
Structure source
AlphaFold
EC
2.7.4.1
GO
GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0009358 A protein complex that possesses polyphosphate kinase activity. GO:0006799 The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0008976 Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).
  • GO:0009358 A protein complex that possesses polyphosphate kinase activity.
  • GO:0006799 The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
113 301 Gene3D G3DSA:3.30.1840.10 Polyphosphate kinase middle domain
113 301 InterPro IPR036830 Polyphosphate kinase middle domain superfamily
3 682 PANTHER PTHR30218 POLYPHOSPHATE KINASE
3 682 InterPro IPR003414 Polyphosphate kinase
6 685 Hamap MF_00347 Polyphosphate kinase [ppk].
6 685 InterPro IPR003414 Polyphosphate kinase
9 112 Pfam PF13089 Polyphosphate kinase N-terminal domain
9 112 InterPro IPR025198 Polyphosphate kinase N-terminal domain
504 671 Pfam PF13090 Polyphosphate kinase C-terminal domain 2
504 671 InterPro IPR025200 Polyphosphate kinase C-terminal domain 2
332 494 Pfam PF17941 Polyphosphate kinase C-terminal domain 1
332 494 InterPro IPR041108 Polyphosphate kinase, C-terminal domain 1
8 677 NCBIfam TIGR03705 polyphosphate kinase 1
8 677 InterPro IPR003414 Polyphosphate kinase
1 685 PIRSF PIRSF015589 PPK_bact
1 685 InterPro IPR003414 Polyphosphate kinase
500 663 CDD cd09168 PLDc_PaPPK1_C2_like
319 501 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
9 112 Gene3D G3DSA:1.20.58.310 -
316 497 SUPERFAMILY SSF56024 Phospholipase D/nuclease
332 493 CDD cd09165 PLDc_PaPPK1_C1_like
110 315 SUPERFAMILY SSF143724 PHP14-like
502 685 Gene3D G3DSA:3.30.870.10 Endonuclease Chain A
122 321 Pfam PF02503 Polyphosphate kinase middle domain
122 321 InterPro IPR024953 Polyphosphate kinase middle domain
4 107 SUPERFAMILY SSF140356 PPK N-terminal domain-like
4 107 InterPro IPR036832 Polyphosphate kinase N-terminal domain superfamily
502 683 SUPERFAMILY SSF56024 Phospholipase D/nuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00015
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.611
6 0.236

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.98 0.741
2 11.53 0.531
3 7.85 0.351
4 7.11 0.309
5 6.99 0.303