Bacterial genome

NZ_AP023069.1

Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

Source: Public Organism: Neisseria gonorrhoeae Sequence length: 2,167,602 bp Strain: TUM19854 Completion: Complete genome
Proteins Add data Custom score EC tree BLAST
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Proteins 62
With 3D structure 62
Annotated 41
With pocket score 56

Top drug-target candidates

Ranked by the Druggability score computed from FPocket pockets (0–1). Higher values indicate more druggable binding sites.

  1. #1 HT085_RS00165 Druggability 0 156+ binders PDB co-crystallized ligands, ChEMBL bioactive compounds (top 100), and ZINC proposals (top 50). Source databases may contain additional records.

    class II fructose-bisphosphate aldolase

    No druggable pocket
  2. #2 HT085_RS00225 Druggability 0 95+ binders PDB co-crystallized ligands, ChEMBL bioactive compounds (top 100), and ZINC proposals (top 50). Source databases may contain additional records.

    acetyl-CoA carboxylase biotin carboxylase subunit

    No druggable pocket
  3. #3 HT085_RS00245 Druggability 0 93+ binders PDB co-crystallized ligands, ChEMBL bioactive compounds (top 100), and ZINC proposals (top 50). Source databases may contain additional records.

    carbamoyl-phosphate synthase large subunit

    No druggable pocket
  4. #4 HT085_RS00030 Druggability 0 92+ binders PDB co-crystallized ligands, ChEMBL bioactive compounds (top 100), and ZINC proposals (top 50). Source databases may contain additional records.

    leucine--tRNA ligase

    No druggable pocket
  5. #5 HT085_RS00175 Druggability 0 90+ binders PDB co-crystallized ligands, ChEMBL bioactive compounds (top 100), and ZINC proposals (top 50). Source databases may contain additional records.

    1-deoxy-D-xylulose-5-phosphate synthase

    No druggable pocket

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Strongest ligand support

Proteins with ligands reported for the same protein are ranked first. Ligands inferred from similar proteins and proposed ZINC compounds are shown separately.

  1. #1 HT085_RS00165 0 direct

    class II fructose-bisphosphate aldolase

    Via homologs 106+ Includes PDB and ChEMBL evidence inferred from similar proteins. ChEMBL similar-protein records are capped at top 100 by pchembl. ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  2. #2 HT085_RS00225 0 direct

    acetyl-CoA carboxylase biotin carboxylase subunit

    Via homologs 45 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  3. #3 HT085_RS00245 0 direct

    carbamoyl-phosphate synthase large subunit

    Via homologs 43 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  4. #4 HT085_RS00030 0 direct

    leucine--tRNA ligase

    Via homologs 42 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher
  5. #5 HT085_RS00175 0 direct

    1-deoxy-D-xylulose-5-phosphate synthase

    Via homologs 40 ZINC 50+ Capped at top 50 by Tanimoto — true count is higher

PDB co-crystal ligands and ChEMBL bioactivity data reported for this exact protein are ranked first.

Evidence available

Computed analyses available for proteins in this genome.

3D structures 62 proteins
  • Loaded experimental3
  • PDB xref proteins3
  • PDB xref entries19
  • AlphaFold44
  • ColabFold18
Functional annotation 41 annotated proteins
  • EC16
  • GO41
Ligand evidence for this genome All via homologs 2295 total records · 39 proteins
  • PDB co-crystal0
  • PDB via homologs299
  • ChEMBL bioactive0
  • ChEMBL via homologs264
  • ZINC proposed1732
CDS 62 CDS untranslated 11 RNA features 2 Total features 75

Note: PDB and ChEMBL records on this protein are the strongest ligand evidence. Similar-protein records are inferred from related proteins and should be interpreted as transferred evidence. ChEMBL similar-protein records are capped at the top 100 per protein and ZINC at the top 50 candidates.

Downloads

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Imported genome details

Properties imported from the source record.

Show imported genome details
Sequence length [bp] 2167602
Gene features 75
Protein-coding features 73
tRNA features 2
COUNT STRUCTS 0
GC 0.0