Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: HT085_RS00080
Assembly: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene: NGO_0016 N776_09265 secG NGK_0022 ESCNG_30035 TUM19854C_00120
Status: annotated
Amino acids: 116
Structure source: AlphaFold

GO

GO:0009306 The controlled release of proteins from a cell. GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0009306 The controlled release of proteins from a cell.
GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0065002 The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
56	78	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
79	116	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6	78	NCBIfam	TIGR00810	preprotein translocase subunit SecG
6	78	InterPro	IPR004692	Preprotein translocase SecG subunit
7	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
43	59	PRINTS	PR01651	Protein-export SecG membrane protein signature
43	59	InterPro	IPR004692	Preprotein translocase SecG subunit
26	40	PRINTS	PR01651	Protein-export SecG membrane protein signature
26	40	InterPro	IPR004692	Preprotein translocase SecG subunit
59	81	PRINTS	PR01651	Protein-export SecG membrane protein signature
59	81	InterPro	IPR004692	Preprotein translocase SecG subunit
6	26	PRINTS	PR01651	Protein-export SecG membrane protein signature
6	26	InterPro	IPR004692	Preprotein translocase SecG subunit
8	78	Pfam	PF03840	Preprotein translocase SecG subunit
8	78	InterPro	IPR004692	Preprotein translocase SecG subunit
89	116	MobiDBLite	mobidb-lite	consensus disorder prediction
5	116	PANTHER	PTHR34182	PROTEIN-EXPORT MEMBRANE PROTEIN SECG
5	116	InterPro	IPR004692	Preprotein translocase SecG subunit
56	78	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	25	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	6	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
26	55	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold HT085_RS00080	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.621
2				0.354

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				1.55	0.019
2				1.53	0.019

HT085_RS00080