Protein profile

HT085_RS00090

GAF domain-containing protein

Genome: NZ_AP023069.1

Gene: WHOF_00016 ESCNG_30033 ytsP TUM19854C_00140 WHOF_00408 msrC Structure source: AlphaFold
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Amino acids 167
Annotations 3
Features 9
PDB binders 1

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00090
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
WHOF_00016 ESCNG_30033 ytsP TUM19854C_00140 WHOF_00408 msrC
Status
annotated
Amino acids
167
Structure source
AlphaFold
EC
1.8.4.14
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745 Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket High
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0033745 Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
3 156 SUPERFAMILY SSF55781 GAF domain-like
5 148 PANTHER PTHR21021 GAF/PUTATIVE CYTOSKELETAL PROTEIN
1 167 Gene3D G3DSA:3.30.450.40 -
1 167 InterPro IPR029016 GAF-like domain superfamily
3 161 FunFam G3DSA:3.30.450.40:FF:000008 GAF domain-containing proteins
31 167 SMART SM00065 gaf_1
31 167 InterPro IPR003018 GAF domain
36 154 Pfam PF13185 GAF domain
36 154 InterPro IPR003018 GAF domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00090
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.838
1 0.484

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.5 0.531

Ligand evidence

Ligands grouped by evidence source — prioritize those reported for this exact protein.

24 records

Structural evidence inferred from similar proteins. The UniProt column identifies the protein that carried the ligand in PDB.

Show only:
Ligand PDB structure UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
SME 3ko6 P36088 165.2 Da LogP -0.83 TPSA 80.4 ✓ Ro5 ✓ Clean C[S@@](=O)CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.