Protein profile

HT085_RS00120

helix-turn-helix transcriptional regulator

Genome: NZ_AP023069.1

Gene: TUM19854C_00200 Structure source: ColabFold
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Amino acids 318
Annotations 1
Features 12
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00120
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
TUM19854C_00200
Status
annotated
Amino acids
318
Structure source
ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket High
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
234 316 InterPro IPR018060 DNA binding HTH domain, AraC-type
270 317 SUPERFAMILY SSF46689 Homeodomain-like
270 317 InterPro IPR009057 Homeobox-like domain superfamily
221 318 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
221 318 InterPro IPR018060 DNA binding HTH domain, AraC-type
218 264 SUPERFAMILY SSF46689 Homeodomain-like
218 264 InterPro IPR009057 Homeobox-like domain superfamily
210 317 PANTHER PTHR47893 REGULATORY PROTEIN PCHR
240 316 Pfam PF12833 Helix-turn-helix domain
240 316 InterPro IPR018060 DNA binding HTH domain, AraC-type
212 318 Gene3D G3DSA:1.10.10.60 -
234 316 SMART SM00342 aracneu4

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold HT085_RS00120
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.896