Protein profile

HT085_RS00170

tyrosine recombinase XerC

Genome: NZ_AP023069.1

Gene: N776_09165 TUM19854C_00300 NCTC11421_02894 WHOF_00392 WHOF_00032 NGK_0043 NGO_0035 ESCNG_30017 E8M63_03355 xerC Structure source: AlphaFold UniProt Q5FAI3 UniProt B4RNW5 UniProt A0AA44U8J9 UniProt A0A1D3FLG3
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Amino acids 305
Annotations 6
Features 20
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00170
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
N776_09165 TUM19854C_00300 NCTC11421_02894 WHOF_00392 WHOF_00032 NGK_0043 NGO_0035 ESCNG_30017 E8M63_03355 xerC
Status
annotated
Amino acids
305
Structure source
AlphaFold
GO
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009037 Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009037 Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
11 96 Pfam PF02899 Phage integrase, N-terminal SAM-like domain
11 96 InterPro IPR004107 Integrase, SAM-like, N-terminal
13 302 NCBIfam TIGR02224 tyrosine recombinase XerC
13 302 InterPro IPR011931 Tyrosine recombinase XerC
114 294 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
114 294 InterPro IPR002104 Integrase, catalytic domain
120 285 Pfam PF00589 Phage integrase family
120 285 InterPro IPR002104 Integrase, catalytic domain
117 293 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
117 293 InterPro IPR013762 Integrase-like, catalytic domain superfamily
6 293 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
6 293 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
7 105 Gene3D G3DSA:1.10.150.130 -
7 105 InterPro IPR010998 Integrase/recombinase, N-terminal
121 289 CDD cd00798 INT_XerDC_C
8 300 Hamap MF_01808 Tyrosine recombinase XerC [xerC].
8 300 InterPro IPR023009 Tyrosine recombinase XerC/XerD
6 284 PANTHER PTHR30629 PROPHAGE INTEGRASE
1 93 ProSiteProfiles PS51900 Core-binding (CB) domain profile.
1 93 InterPro IPR044068 Core-binding (CB) domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00170
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.672
2 0.403

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.09 0.192
2 2.84 0.072
3 1.88 0.031
4 1.85 0.03
5 1.46 0.016