Protein profile

HT085_RS00255

ComF family protein

Genome: NZ_AP023069.1

Gene: ESCNG_30002 N776_09085 HMPREF0602_1736 DE8555_0356 E8M63_06565 NMC0365 TUM19854C_00410 NMA0604 CNQ34_06115 ERS514851_01862 CIJ84_07505 Structure source: AlphaFold UniProt A0AA44UAL1 UniProt A0A0U1RHL3 UniProt A1KS44 UniProt A0AAQ1E0J3 UniProt A0A0E1ID65 UniProt E0NB54
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Amino acids 187
Annotations 1
Features 10
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00255
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
ESCNG_30002 N776_09085 HMPREF0602_1736 DE8555_0356 E8M63_06565 NMC0365 TUM19854C_00410 NMA0604 CNQ34_06115 ERS514851_01862 CIJ84_07505
Status
annotated
Amino acids
187
Structure source
AlphaFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
41 185 PANTHER PTHR47505 DNA UTILIZATION PROTEIN YHGH
48 183 SUPERFAMILY SSF53271 PRTase-like
48 183 InterPro IPR029057 Phosphoribosyltransferase-like
92 187 Gene3D G3DSA:3.40.50.2020 -
92 187 InterPro IPR029057 Phosphoribosyltransferase-like
120 140 Coils Coil Coil
95 179 Pfam PF00156 Phosphoribosyl transferase domain
95 179 InterPro IPR000836 Phosphoribosyltransferase domain
95 182 CDD cd06223 PRTases_typeI
95 182 InterPro IPR000836 Phosphoribosyltransferase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00255
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.66

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.57 0.221
2 1.79 0.028