Protein profile

HT085_RS00260

endonuclease domain-containing protein

Genome: NZ_AP023069.1

Gene: WHOF_00050C N776_09080 ESCNG_530001 E8M63_06550 WHOF_01971 NGO_0050 TUM19854C_00420 NGK_0065 Structure source: Experimental + AlphaFold UniProt A0AA44U8T2 UniProt Q5FAH0 UniProt Q9ZIE8 UniProt B4RNY7
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Amino acids 129
Annotations 0
Features 11
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00260
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
WHOF_00050C N776_09080 ESCNG_530001 E8M63_06550 WHOF_01971 NGO_0050 TUM19854C_00420 NGK_0065
Status
annotated
Amino acids
129
Structure source
Experimental + AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
8 122 PANTHER PTHR38590 BLL0828 PROTEIN
8 122 InterPro IPR047216 Putative endonuclease DUF559, bacteria
26 120 CDD cd01038 Endonuclease_DUF559
26 120 InterPro IPR047216 Putative endonuclease DUF559, bacteria
12 123 SUPERFAMILY SSF52980 Restriction endonuclease-like
12 123 InterPro IPR011335 Restriction endonuclease type II-like
23 126 Gene3D G3DSA:3.40.960.10 VSR Endonuclease
106 126 Coils Coil Coil
12 39 Coils Coil Coil
15 121 Pfam PF04480 Protein of unknown function (DUF559)
15 121 InterPro IPR007569 Domain of unknown function DUF559

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3HRL
X-ray 1.95 Å A
77.5% 27-126
PDBe RCSB PDBj File
Viewing
AlphaFold HT085_RS00260
AlphaFold — — full sequence — Loaded
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