Protein target profile

HT085_RS00275

PilC family type IV pilus tip adhesin

Genome: NZ_AP023069.1 Gene: pilC TUM19854C_00460 3D evidence: ColabFold model

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Length 1054

Functional annotation 0 EC 0 GO

Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

Automated synthesis of the evidence currently loaded. Review the underlying records before prioritizing this protein.

Main supporting evidence

No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Structure available ColabFold model

Risks to review

No major risk signal surfaced in the loaded evidence.

Evidence gaps

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No FPocket pocket score No selected computational pocket-druggability value is available. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.

Terms and data sources used on this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal Target pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Prioritization evidence

Selectivity, essentiality, structural confidence, conservation, and predicted binding-site evidence.

Off-target risk

Human off-target: No hit
Gut microbiome off-target: Hit

Essentiality

Essential (DEG): N

Localization

Localization: OuterMembrane

Binding-site evidence

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket Low

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MNKTLKRRVFRHTALYAAILMFSHTGGGGAMAQTHKYAIIMNERKQPEVKWETQYSQSALKDKGRERTFSHTSQKGRFNITHNFISFNNNDTLVSQQSGTAVFGTATYLPPYGKVSGFDADGLKKRNNAVNWIRTTRPGLAGYGYTGIRCGSTKDCPKLTYKTRFSFDNTDLVETRGGLDRHTEPSRENSPIYKLKDYPWLGVSFNLGAEGTAKDGRSSSRLISSFDENNSNSNQNLVYTTEDHRISLGNWQHETTAMAYYLNAKLHLLDKEKIKDITGKTVRLGVLKPSIDVKTQNTGLSGILNFWSKWDIKDNGQIPVKLGLPEVKAGRCINKPNPNNNTKAPSPALTAPALWFGPVQNGKVQMYSASVSTYPGSSSSRIFLQELKTQTDPARPGRHSLAALNTQDIKSREPNFNSRQTVIRLPGGVYRIAPTRDRIVGLNGNDGKNDTFGIYKDRLVTPEADEWAKVLLPWTVRYYGNDDIFKTFNQPNNKKQSDKKQYSQKYRIRTKEDDNDKPRDLGDIVNSPIVAVGGYLATAANDGMVHIFKKTGTDERGYELKLSYIPGTMPRQYFDNDTSTLKDSTLAQELRTFAEKGYVGDRYGVDGGFVLRRITDDQDKQKHFFMFGAMGLGGRGAYALDLSKIDSSNLTGVSMFDVQNDKNNNNNKNDNNRVKLGYTVGTPQIGKTQNGKYAAFLASGYAAKNIGSGDNTTALYVYDLENTSGSLIKKIEAPGGKGGLSSPTLVDKDLDGTVDIAYAGDRGGNMYRFDLSDSNPDKWSVRTIFEGDKPITSAPAVSRLADKRVVIFGTGSDLTEDDVLNTGEQYIYGIFDDDKAANNVNASRGVLGSGLLEQHLTQENKTLFLNKRSDGSGSKGWAVKLTGGRRVTVKPTVVLRTAFVTIRKYKDDGCGAETAILGINTADGGALTPRSARPIVPDHNSVAQYSGHQKMNGKSIPIGCMWKNSKTVCPNGYVYDKPVNVRYLDEKKTDDFPVTADGDAGGSGTFKEGKKPARNNRCFSGKGVRTLLMNDLDSLDITGPMCGIKRLSWREVFF

MNKTLKRRVFRHTALYAAILMFSHTGGGGAMAQTHKYAIIMNERKQPEVKWETQYSQSALKDKGRERTFSHTSQKGRFNITHNFISFNNNDTLVSQQSGTAVFGTATYLPPYGKVSGFDADGLKKRNNAVNWIRTTRPGLAGYGYTGIRCGSTKDCPKLTYKTRFSFDNTDLVETRGGLDRHTEPSRENSPIYKLKDYPWLGVSFNLGAEGTAKDGRSSSRLISSFDENNSNSNQNLVYTTEDHRISLGNWQHETTAMAYYLNAKLHLLDKEKIKDITGKTVRLGVLKPSIDVKTQNTGLSGILNFWSKWDIKDNGQIPVKLGLPEVKAGRCINKPNPNNNTKAPSPALTAPALWFGPVQNGKVQMYSASVSTYPGSSSSRIFLQELKTQTDPARPGRHSLAALNTQDIKSREPNFNSRQTVIRLPGGVYRIAPTRDRIVGLNGNDGKNDTFGIYKDRLVTPEADEWAKVLLPWTVRYYGNDDIFKTFNQPNNKKQSDKKQYSQKYRIRTKEDDNDKPRDLGDIVNSPIVAVGGYLATAANDGMVHIFKKTGTDERGYELKLSYIPGTMPRQYFDNDTSTLKDSTLAQELRTFAEKGYVGDRYGVDGGFVLRRITDDQDKQKHFFMFGAMGLGGRGAYALDLSKIDSSNLTGVSMFDVQNDKNNNNNKNDNNRVKLGYTVGTPQIGKTQNGKYAAFLASGYAAKNIGSGDNTTALYVYDLENTSGSLIKKIEAPGGKGGLSSPTLVDKDLDGTVDIAYAGDRGGNMYRFDLSDSNPDKWSVRTIFEGDKPITSAPAVSRLADKRVVIFGTGSDLTEDDVLNTGEQYIYGIFDDDKAANNVNASRGVLGSGLLEQHLTQENKTLFLNKRSDGSGSKGWAVKLTGGRRVTVKPTVVLRTAFVTIRKYKDDGCGAETAILGINTADGGALTPRSARPIVPDHNSVAQYSGHQKMNGKSIPIGCMWKNSKTVCPNGYVYDKPVNVRYLDEKKTDDFPVTADGDAGGSGTFKEGKKPARNNRCFSGKGVRTLLMNDLDSLDITGPMCGIKRLSWREVFF

Functional annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence domains and features

Domain and signature matches imported from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
1	32	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	12	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
33	1054	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	32	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	1054	NCBIfam	NF040838	neisserial PilC family type IV pilus tip adhesin
521	866	Pfam	PF05567	Neisseria PilC beta-propeller domain
521	866	InterPro	IPR008707	PilC beta-propeller domain
13	23	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
24	32	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	32	Phobius	SIGNAL_PEPTIDE	Signal peptide region
683	813	SUPERFAMILY	SSF89372	Fucose-specific lectin

3D structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

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Pocket score High Medium Low

How colors and pocket overlays are used

Uniform protein color marks the displayed model as a single molecular object.

Experimental PDB structures may be colored by chain to distinguish subunits or copies present in the file.

Pocket colors and alpha spheres are evidence overlays for predicted binding cavities; they are not alternative protein chains.

Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #6

0.274

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Surrounding area

Site 2 FPocket #1

0.203

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Surrounding area

All structural evidence 0 experimental · 1 predicted

Structural evidence

0 + 1

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold HT085_RS00275	ColabFold	—	—	full sequence	—	Viewing