Protein profile

HT085_RS00275

PilC family type IV pilus tip adhesin

Genome: NZ_AP023069.1

Gene: pilC TUM19854C_00460 Structure source: ColabFold

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Amino acids 1054

Annotations 0

Features 12

PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession: HT085_RS00275
Assembly: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene: pilC TUM19854C_00460
Status: annotated
Amino acids: 1054
Structure source: ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Low

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MNKTLKRRVFRHTALYAAILMFSHTGGGGAMAQTHKYAIIMNERKQPEVKWETQYSQSALKDKGRERTFSHTSQKGRFNITHNFISFNNNDTLVSQQSGTAVFGTATYLPPYGKVSGFDADGLKKRNNAVNWIRTTRPGLAGYGYTGIRCGSTKDCPKLTYKTRFSFDNTDLVETRGGLDRHTEPSRENSPIYKLKDYPWLGVSFNLGAEGTAKDGRSSSRLISSFDENNSNSNQNLVYTTEDHRISLGNWQHETTAMAYYLNAKLHLLDKEKIKDITGKTVRLGVLKPSIDVKTQNTGLSGILNFWSKWDIKDNGQIPVKLGLPEVKAGRCINKPNPNNNTKAPSPALTAPALWFGPVQNGKVQMYSASVSTYPGSSSSRIFLQELKTQTDPARPGRHSLAALNTQDIKSREPNFNSRQTVIRLPGGVYRIAPTRDRIVGLNGNDGKNDTFGIYKDRLVTPEADEWAKVLLPWTVRYYGNDDIFKTFNQPNNKKQSDKKQYSQKYRIRTKEDDNDKPRDLGDIVNSPIVAVGGYLATAANDGMVHIFKKTGTDERGYELKLSYIPGTMPRQYFDNDTSTLKDSTLAQELRTFAEKGYVGDRYGVDGGFVLRRITDDQDKQKHFFMFGAMGLGGRGAYALDLSKIDSSNLTGVSMFDVQNDKNNNNNKNDNNRVKLGYTVGTPQIGKTQNGKYAAFLASGYAAKNIGSGDNTTALYVYDLENTSGSLIKKIEAPGGKGGLSSPTLVDKDLDGTVDIAYAGDRGGNMYRFDLSDSNPDKWSVRTIFEGDKPITSAPAVSRLADKRVVIFGTGSDLTEDDVLNTGEQYIYGIFDDDKAANNVNASRGVLGSGLLEQHLTQENKTLFLNKRSDGSGSKGWAVKLTGGRRVTVKPTVVLRTAFVTIRKYKDDGCGAETAILGINTADGGALTPRSARPIVPDHNSVAQYSGHQKMNGKSIPIGCMWKNSKTVCPNGYVYDKPVNVRYLDEKKTDDFPVTADGDAGGSGTFKEGKKPARNNRCFSGKGVRTLLMNDLDSLDITGPMCGIKRLSWREVFF

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
1	32	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	12	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
33	1054	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	32	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	1054	NCBIfam	NF040838	neisserial PilC family type IV pilus tip adhesin
521	866	Pfam	PF05567	Neisseria PilC beta-propeller domain
521	866	InterPro	IPR008707	PilC beta-propeller domain
13	23	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
24	32	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	32	Phobius	SIGNAL_PEPTIDE	Signal peptide region
683	813	SUPERFAMILY	SSF89372	Fucose-specific lectin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold HT085_RS00275	ColabFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.203