Protein profile

HT085_RS00290

protein disulfide oxidoreductase

Genome: NZ_AP023069.1

Gene: WHOF_00057 WHOF_01987 resA_1 E8M63_11545 NGO_0057 resA_3 NGK_0080 N776_09035 ESCNG_350003 TUM19854C_00480 Structure source: AlphaFold UniProt A0AA44U8I0 UniProt Q5FAG5 UniProt A0A1D3G0B6 UniProt B4RP02
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Amino acids 169
Annotations 2
Features 14
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00290
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
WHOF_00057 WHOF_01987 resA_1 E8M63_11545 NGO_0057 resA_3 NGK_0080 N776_09035 ESCNG_350003 TUM19854C_00480
Status
annotated
Amino acids
169
Structure source
AlphaFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket High
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0016209 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
42 163 CDD cd03011 TlpA_like_ScsD_MtbDsbE
15 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
33 165 Gene3D G3DSA:3.40.30.10 Glutaredoxin
30 167 ProSiteProfiles PS51352 Thioredoxin domain profile.
30 167 InterPro IPR013766 Thioredoxin domain
52 162 PANTHER PTHR42852 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE
39 169 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 14 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
43 149 Pfam PF08534 Redoxin
43 149 InterPro IPR013740 Redoxin
35 162 SUPERFAMILY SSF52833 Thioredoxin-like
35 162 InterPro IPR036249 Thioredoxin-like superfamily
27 38 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 38 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00290
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.777
3 0.266

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.8 0.002