Protein profile

HT085_RS00370

signal peptidase II

Genome: NZ_AP023069.1

Gene: lspA TUM19854C_00610 ESCNG_80002 E8M63_05140 NGO_0071 NCTC10616_00071 Structure source: AlphaFold UniProt Q5FAF3 UniProt A0AAQ1E1J1 UniProt A0A378VI18
Export view
Amino acids 164
Annotations 4
Features 29
PDB binders 3

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00370
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
lspA TUM19854C_00610 ESCNG_80002 E8M63_05140 NGO_0071 NCTC10616_00071
Status
annotated
Amino acids
164
Structure source
AlphaFold
EC
3.4.23.36
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket High
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
130 152 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 153 Pfam PF01252 Signal peptidase (SPase) II
15 153 InterPro IPR001872 Peptidase A8, signal peptidase II
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
92 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 161 Hamap MF_00161 Lipoprotein signal peptidase [lspA].
7 161 InterPro IPR001872 Peptidase A8, signal peptidase II
132 152 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
100 115 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature
100 115 InterPro IPR001872 Peptidase A8, signal peptidase II
136 152 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature
136 152 InterPro IPR001872 Peptidase A8, signal peptidase II
53 61 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature
53 61 InterPro IPR001872 Peptidase A8, signal peptidase II
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 131 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
62 66 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 163 NCBIfam TIGR00077 signal peptidase II
8 163 InterPro IPR001872 Peptidase A8, signal peptidase II
153 164 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
30 40 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 162 PANTHER PTHR33695 LIPOPROTEIN SIGNAL PEPTIDASE
8 162 InterPro IPR001872 Peptidase A8, signal peptidase II
86 91 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00370
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.797
4 0.391
2 0.281

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.84 0.711
2 2.17 0.043
3 1.84 0.03
4 1.79 0.028
5 1.51 0.018

Ligand evidence

Ligands grouped by evidence source — prioritize those reported for this exact protein.

53 records

Structural evidence inferred from similar proteins. The UniProt column identifies the protein that carried the ligand in PDB.

Show only:
Ligand PDB structure UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
7PE 6ryo Q6GHN9 310.4 Da LogP 0.10 TPSA 75.6 ✓ Ro5 ✓ Clean CCOCCOCCOCCOCCOCCOCCO
KNH 6ryp Q6GHN9 623.9 Da LogP 5.20 TPSA 142.4 2 viol. ✓ Clean CCC[C@H]1C(=O)NC[C@H](C[C@@H]([C@@H](CC/C(=C/C=…
OLC 6ryo Q6GHN9 356.5 Da LogP 4.92 TPSA 66.8 ✓ Ro5 ✓ Clean CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](CO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.