Protein profile

HT085_RS00385

HAD-IA family hydrolase

Genome: NZ_AP023069.1

Gene: E8M63_05115 TUM19854C_00640 Structure source: AlphaFold UniProt A0AAX2C0Z5
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Amino acids 219
Annotations 3
Features 13
PDB binders 10

Overview

Basic information about this protein and its source genome.

Accession
HT085_RS00385
Assembly
Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome
Gene
E8M63_05115 TUM19854C_00640
Status
annotated
Amino acids
219
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008967 Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket Medium
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008967 Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate.
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 212 PANTHER PTHR43434 PHOSPHOGLYCOLATE PHOSPHATASE
7 185 Pfam PF13419 Haloacid dehalogenase-like hydrolase
7 185 InterPro IPR041492 Haloacid dehalogenase-like hydrolase
133 179 NCBIfam TIGR01549 HAD-IA family hydrolase
133 179 InterPro IPR006439 HAD hydrolase, subfamily IA
4 215 SFLD SFLDG01135 C1.5.6: HAD, Beta-PGM, Phosphatase Like
4 215 SFLD SFLDG01129 C1.5: HAD, Beta-PGM, Phosphatase Like
5 214 SUPERFAMILY SSF56784 HAD-like
5 214 InterPro IPR036412 HAD-like superfamily
19 83 Gene3D G3DSA:1.10.150.240 Putative phosphatase; domain 2
19 83 InterPro IPR023198 Phosphoglycolate phosphatase-like, domain 2
7 199 Gene3D G3DSA:3.40.50.1000 -
7 199 InterPro IPR023214 HAD superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold HT085_RS00385
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.667
4 0.386

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.49 0.605
2 3.43 0.099

Ligand evidence

Ligands grouped by evidence source — prioritize those reported for this exact protein.

27 records

Structural evidence inferred from similar proteins. The UniProt column identifies the protein that carried the ligand in PDB.

Show only:
Ligand PDB structure UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ALF 6h8w P71447 103.0 Da LogP 1.30 TPSA 0.0 ✓ Ro5 ✓ Clean F[Al-](F)(F)F
BEF 2wfa P71447 66.0 Da LogP 0.88 TPSA 0.0 ✓ Ro5 ✓ Clean [Be-](F)(F)F
BO3 4ex7 B6SEG4 61.8 Da LogP -2.05 TPSA 60.7 ✓ Ro5 ✓ Clean B(O)(O)O
ESA 1rdf O31156 110.1 Da LogP -0.11 TPSA 54.4 ✓ Ro5 ✓ Clean CCS(=O)(=O)O
MGF 6h8x P71447 81.3 Da LogP 0.88 TPSA 0.0 ✓ Ro5 ✓ Clean F[Mg-](F)F
POA 1sww O31156 124.0 Da LogP -0.64 TPSA 74.6 ✓ Ro5 ✓ Clean C(C=O)P(=O)(O)O
UVW 6h91 P71447 140.0 Da LogP -0.36 TPSA 83.8 ✓ Ro5 ✓ Clean CC(=O)OP(=O)(O)O
VO4 4knw Q8TBE9 114.9 Da LogP -3.69 TPSA 86.2 ✓ Ro5 ✓ Clean [O-][V](=O)([O-])[O-]
VSO 1rql O31156 108.1 Da LogP 0.02 TPSA 54.4 ✓ Ro5 ✓ Clean C=CS(=O)(=O)O
WO4 1fez O31156 247.8 Da LogP -2.62 TPSA 80.3 ✓ Ro5 ✓ Clean [O-][W](=O)(=O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.