Protein profile

PA0012

hypothetical protein

Genome: NC_002516.2

Gene: PA0012 Structure source: Experimental + AlphaFold UniProt Q9I7B4
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Amino acids 88
Annotations 1
Features 4
PDB binders 0
Druggability 0.951

Overview

Basic information about this protein and its source genome.

Accession
PA0012
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0012
Status
annotated
Amino acids
88
Structure source
Experimental + AlphaFold
GO
GO:0035438 Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.951
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0035438 Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
2 88 Gene3D G3DSA:2.40.10.220 predicted glycosyltransferase like domains
1 86 SUPERFAMILY SSF141371 PilZ domain-like
4 85 Pfam PF07238 PilZ domain
4 85 InterPro IPR009875 PilZ domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8U0I
X-ray 1.54 Å A
100.0% 1-88
PDBe RCSB PDBj File
Viewing
AlphaFold PA0012
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.951

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.79 0.347
2 3.04 0.1