Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0026
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: plcB PA0026
Status: annotated
Amino acids: 328
Structure source: AlphaFold

GO

GO:0016298 Catalysis of the hydrolysis of a lipid. GO:0004629 A glycerophospholipase activity that cleaves the first phosphodiester bond between the phosphate and glycerol, producing a mono- or a diacylglycerol, depending on whether the substrate is a lysoglycerophospholipid or a glycerophospholipid. GO:0008270 Binding to a zinc ion (Zn). GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.803

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7

GO:0016298 Catalysis of the hydrolysis of a lipid.
GO:0004629 A glycerophospholipase activity that cleaves the first phosphodiester bond between the phosphate and glycerol, producing a mono- or a diacylglycerol, depending on whether the substrate is a lysoglycerophospholipid or a glycerophospholipid.
GO:0008270 Binding to a zinc ion (Zn).
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
GO:0043952 The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.
GO:0016788 Catalysis of the hydrolysis of any ester bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
1	22	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	22	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
145	324	Gene3D	G3DSA:1.10.575.10	P1 Nuclease
145	324	InterPro	IPR008947	Phospholipase C/P1 nuclease domain superfamily
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
120	317	CDD	cd11009	Zn_dep_PLPC
120	317	InterPro	IPR001531	Zinc-dependent phospholipase C
18	22	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
23	328	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	22	SignalP_EUK	SignalP-noTM	SignalP-noTM
133	320	SUPERFAMILY	SSF48537	Phospholipase C/P1 nuclease
133	320	InterPro	IPR008947	Phospholipase C/P1 nuclease domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0026	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.803
6				0.211

PA0026