Protein profile

PA0027

hypothetical protein

Genome: NC_002516.2

Gene: PA0027 Structure source: AlphaFold UniProt Q9I7A3
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Amino acids 428
Annotations 2
Features 14
PDB binders 0
Druggability 0.908

Overview

Basic information about this protein and its source genome.

Accession
PA0027
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0027
Status
annotated
Amino acids
428
Structure source
AlphaFold
EC
5.2.1.8
GO
GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.908
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
271 391 Pfam PF13145 PPIC-type PPIASE domain
271 391 InterPro IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
289 388 Gene3D G3DSA:3.10.50.40 -
289 388 InterPro IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
292 383 SUPERFAMILY SSF54534 FKBP-like
1 426 PANTHER PTHR47245 PEPTIDYLPROLYL ISOMERASE
26 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
15 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 14 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
31 428 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
290 382 ProSiteProfiles PS50198 PpiC-type peptidyl-prolyl cis-trans isomerase family profile.
290 382 InterPro IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
1 30 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0027
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.908
9 0.228