Protein profile

PA0033

hypothetical protein

Genome: NC_002516.2

Gene: PA0033 Structure source: AlphaFold UniProt Q9I797

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Amino acids 121

Annotations 2

Features 11

PDB binders 0

Druggability 0.895

Overview

Basic information about this protein and its source genome.

Accession: PA0033
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0033
Status: annotated
Amino acids: 121
Structure source: AlphaFold

GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.895

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0004672 Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
24	44	Coils	Coil	Coil
16	109	ProSiteProfiles	PS50894	Histidine-containing phosphotransfer (HPt) domain profile.
16	109	InterPro	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
9	111	SUPERFAMILY	SSF47226	Histidine-containing phosphotransfer domain, HPT domain
9	111	InterPro	IPR036641	HPT domain superfamily
24	99	Pfam	PF01627	Hpt domain
24	99	InterPro	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
18	107	CDD	cd00088	HPT
18	107	InterPro	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
1	114	Gene3D	G3DSA:1.20.120.160	HPT domain
1	114	InterPro	IPR036641	HPT domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0033	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.895
2				0.806