Protein profile

PA0041a

transposase

Genome: NC_002516.2

Gene: YP_008719729.1 Structure source: ColabFold

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Amino acids 233

Annotations 3

Features 9

PDB binders 0

Druggability 0.58

Overview

Basic information about this protein and its source genome.

Accession: PA0041a
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: YP_008719729.1
Status: annotated
Amino acids: 233
Structure source: ColabFold

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.58

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
9	125	SMART	SM01321	Y1_Tnp_2
9	125	InterPro	IPR002686	Transposase IS200-like
1	213	PANTHER	PTHR34322	TRANSPOSASE, Y1_TNP DOMAIN-CONTAINING
1	161	Gene3D	G3DSA:3.30.70.1290	-
1	161	InterPro	IPR036515	Transposase IS200-like superfamily
3	128	SUPERFAMILY	SSF143422	Transposase IS200-like
3	128	InterPro	IPR036515	Transposase IS200-like superfamily
12	123	Pfam	PF01797	Transposase IS200 like
12	123	InterPro	IPR002686	Transposase IS200-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold PA0041A	ColabFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.58