Protein profile

PA0045

hypothetical protein

Genome: NC_002516.2

Gene: PA0045 Structure source: AlphaFold UniProt Q9I787
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Amino acids 228
Annotations 1
Features 14
PDB binders 0
Druggability 0.547

Overview

Basic information about this protein and its source genome.

Accession
PA0045
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0045
Status
annotated
Amino acids
228
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.547
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 24 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
48 225 Pfam PF03783 Curli production assembly/transport component CsgG
48 225 InterPro IPR005534 Curli production assembly/transport component CsgG
33 228 Gene3D G3DSA:3.40.50.10610 -
25 228 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 146 SUPERFAMILY SSF52964 TolB, N-terminal domain
1 31 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
9 227 PANTHER PTHR41164 CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0045
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.547
4 0.401
3 0.347
5 0.339