Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0069
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0069
Status: annotated
Amino acids: 352
Structure source: AlphaFold

GO

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.702

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MSAPLPPRGRGTASNPLNRFAPTHSEAFDDGWEQDVPPIQLTEVREEIARTVISRNQSPDLPFDRSINPYRGCEHGCIYCYARPSHAYWDLSPGIDFETRLIAKSNVASALEQELSKPGYRCAPINLGANTDPYQPLERERRLTRQVLEVLLRFRHPLTIVTKGSLILRDLDLLRELAEQNLVAVMISLTTLDDELKRILEPRAAAPSARLRAIRTLSGNGIPVGVLCSPMIPMVNDMELERLLQAARDAGARSAAYMLLRLPREVGPLFEEWLAAHYPQRAEHVMSLVRQCRGGEVYDSRFGHRFRGQGPFADLLAQRFAVAMKRLGLDRREGFGLDCSRFAVPGAQMALF

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
63	288	SMART	SM00729	MiaB
63	288	InterPro	IPR006638	Elp3/MiaA/NifB-like, radical SAM core domain
1	29	MobiDBLite	mobidb-lite	consensus disorder prediction
41	332	SFLD	SFLDS00029	Radical SAM
41	332	InterPro	IPR007197	Radical SAM
59	296	ProSiteProfiles	PS51918	Radical SAM core domain profile.
59	296	InterPro	IPR007197	Radical SAM
41	334	PANTHER	PTHR43432	SLR0285 PROTEIN
41	334	InterPro	IPR040086	Protein MJ0683-like
8	352	NCBIfam	NF033668	PA0069 family radical SAM protein
106	293	Gene3D	G3DSA:3.80.30.30	-
67	245	Pfam	PF04055	Radical SAM superfamily
67	245	InterPro	IPR007197	Radical SAM
67	245	CDD	cd01335	Radical_SAM
41	332	SFLD	SFLDG01084	Uncharacterised Radical SAM Subgroup 2
41	332	InterPro	IPR040086	Protein MJ0683-like
48	261	SUPERFAMILY	SSF102114	Radical SAM enzymes

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0069	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.702

PA0069