Protein profile

PA0073

ABC transporter ATP-binding protein

Genome: NC_002516.2

Gene: PA0073 Structure source: AlphaFold UniProt Q9I759
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Amino acids 239
Annotations 7
Features 14
PDB binders 5
Druggability 0.484

Overview

Basic information about this protein and its source genome.

Accession
PA0073
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0073
Status
annotated
Amino acids
239
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0044874 A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. GO:0089705 A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.204
Human E-value
2.32e-16
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.484
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0044874 A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.
  • GO:0089705 A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
2 219 PANTHER PTHR24220 IMPORT ATP-BINDING PROTEIN
2 219 InterPro IPR015854 ABC transporter, lipoprotein release, LolD-like
3 235 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile.
3 235 InterPro IPR003439 ABC transporter-like, ATP-binding domain
26 212 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
26 212 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
148 162 ProSitePatterns PS00211 ABC transporters family signature.
148 162 InterPro IPR017871 ABC transporter-like, conserved site
30 225 SMART SM00382 AAA_5
30 225 InterPro IPR003593 AAA+ ATPase domain
10 225 Gene3D G3DSA:3.40.50.300 -
10 225 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
26 176 Pfam PF00005 ABC transporter
26 176 InterPro IPR003439 ABC transporter-like, ATP-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0073
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.484

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AGS
3C4J
D0VWX4 523.2 Da LogP -1.51 TPSA 262.1 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
ANP
3C41
D0VWX4 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
AT4
5WS4
A0A0D8G707 443.3 Da LogP -0.81 TPSA 212.4 2 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
NH4
1G29
Q9YGA6 18.0 Da LogP 0.38 TPSA 36.5 ✓ Ro5 ✓ Clean [NH4+]
POP
2D62
O57933 176.0 Da LogP -2.08 TPSA 129.9 ✓ Ro5 ✓ Clean O[P@@](=O)([O-])O[P@@](=O)(O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.