Protein profile

PA0075

serine/threonine phosphatase

Genome: NC_002516.2

Gene: PA0075 pppA Structure source: Experimental + AlphaFold UniProt Q9I757
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Amino acids 242
Annotations 5
Features 15
PDB binders 0
Druggability 0.212

Overview

Basic information about this protein and its source genome.

Accession
PA0075
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0075 pppA
Status
annotated
Amino acids
242
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion. GO:0004722 Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0006470 The process of removing one or more phosphoric residues from a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.212
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0046872 Binding to a metal ion.
  • GO:0004722 Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
  • GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0006470 The process of removing one or more phosphoric residues from a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
21 207 Pfam PF13672 Protein phosphatase 2C
19 239 PANTHER PTHR13832 PROTEIN PHOSPHATASE 2C
19 239 InterPro IPR015655 Protein phosphatase 2C family
6 239 SMART SM00332 PP2C_4
6 239 InterPro IPR001932 PPM-type phosphatase-like domain
9 240 SUPERFAMILY SSF81606 PP2C-like
9 240 InterPro IPR036457 PPM-type phosphatase-like domain superfamily
15 241 SMART SM00331 PP2C_SIG_2
15 241 InterPro IPR001932 PPM-type phosphatase-like domain
3 241 Gene3D G3DSA:3.60.40.10 -
3 241 InterPro IPR036457 PPM-type phosphatase-like domain superfamily
8 241 ProSiteProfiles PS51746 PPM-type phosphatase domain profile.
8 241 InterPro IPR001932 PPM-type phosphatase-like domain
10 240 CDD cd00143 PP2Cc
10 240 InterPro IPR001932 PPM-type phosphatase-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6JKV
X-ray 2.10 Å A,B
100.0% 1-242
PDBe RCSB PDBj File
Viewing
AlphaFold PA0075
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.212

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.47 0.509
2 4.81 0.213