Protein profile
PA0077
type VI secretion protein IcmF
Genome: NC_002516.2
Overview
Basic information about this protein and its source genome.
- Accession
- PA0077
- Gene
- icmF1
- Status
- annotated
- Amino acids
- 1101
- Structure source
- ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- CytoplasmicMembrane
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
No GO or EC annotations are currently loaded for this protein.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 370 | 392 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 369 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 976 | 1082 | Pfam | PF06744 | Type VI secretion protein IcmF C2-like domain |
| 976 | 1082 | InterPro | IPR010623 | Type VI secretion system IcmF, C-terminal |
| 120 | 377 | Pfam | PF14331 | IcmF-related N-terminal domain |
| 120 | 377 | InterPro | IPR025743 | IcmF-related, N-terminal domain |
| 21 | 41 | Coils | Coil | Coil |
| 3 | 1101 | PANTHER | PTHR36153 | INNER MEMBRANE PROTEIN-RELATED |
| 8 | 1099 | NCBIfam | TIGR03348 | type VI secretion system membrane subunit TssM |
| 8 | 1099 | InterPro | IPR017731 | Type VI secretion system protein TssM1-like |
| 429 | 722 | Pfam | PF06761 | Intracellular multiplication and human macrophage-killing |
| 429 | 722 | InterPro | IPR009612 | IcmF-related |
| 50 | 219 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases |
| 50 | 219 | InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| 370 | 392 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 393 | 1101 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 55 | 198 | CDD | cd00882 | Ras_like_GTPase |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
ColabFold
PA0077
|
ColabFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 6 | 0.57 | ||||||
| 1 | 0.421 | ||||||
| 3 | 0.278 |