Protein profile

PA0085

protein secretion apparatus assembly protein

Genome: NC_002516.2

Gene: PA0085 hcp1 Structure source: Experimental + AlphaFold UniProt Q9I747
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Amino acids 162
Annotations 2
Features 10
PDB binders 0
Druggability 0.888

Overview

Basic information about this protein and its source genome.

Accession
PA0085
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0085 hcp1
Status
annotated
Amino acids
162
Structure source
Experimental + AlphaFold
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042802 Binding to an identical protein or proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.888
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0042802 Binding to an identical protein or proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 162 FunFam G3DSA:2.30.110.20:FF:000001 Type VI secretion system effector
1 162 Gene3D G3DSA:2.30.110.20 -
1 162 InterPro IPR036624 Hcp1-like superfamily
2 160 SUPERFAMILY SSF141452 Hcp1-like
2 160 InterPro IPR036624 Hcp1-like superfamily
13 144 NCBIfam TIGR03344 type VI secretion system tube protein TssD/Hcp
13 144 InterPro IPR008514 Type VI secretion system effector Hcp
6 136 Pfam PF05638 Type VI secretion system effector, Hcp
6 136 InterPro IPR008514 Type VI secretion system effector Hcp
1 161 PANTHER PTHR36152 CYTOPLASMIC PROTEIN-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1Y12
X-ray 1.95 Å A,B,C
100.0% 1-162
PDBe RCSB PDBj File
Viewing
AlphaFold PA0085
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.93 0.004