Protein profile

PA0093

hypothetical protein

Genome: NC_002516.2

Gene: PA0093 tse6 Structure source: Experimental + AlphaFold UniProt Q9I739
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Amino acids 430
Annotations 6
Features 18
PDB binders 0
Druggability 0.878

Overview

Basic information about this protein and its source genome.

Accession
PA0093
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0093 tse6
Status
annotated
Amino acids
430
Structure source
Experimental + AlphaFold
EC
3.2.2.5
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003953 Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+. GO:0050135 Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose 2'-phosphate + nicotinamide + H+. GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.878
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0003953 Catalysis of the reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide + H+.
  • GO:0050135 Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose 2'-phosphate + nicotinamide + H+.
  • GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
  • GO:0033103 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
216 234 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
80 161 CDD cd14742 PAAR_RHS
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
70 161 Gene3D G3DSA:2.60.200.60 -
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
80 151 Pfam PF05488 PAAR motif
80 151 InterPro IPR008727 PAAR motif
45 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
235 252 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
186 215 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
67 185 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
266 422 Pfam PF15538 Bacterial toxin 46
266 422 InterPro IPR028238 Bacterial toxin 46
253 430 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6OX6
X-ray 2.17 Å A
81.9% 22-373
PDBe RCSB PDBj File
Viewing
PDB 4ZV4
X-ray 3.50 Å C,D
38.6% 265-430
PDBe RCSB PDBj File
Loaded
PDB 4ZV0
X-ray 1.40 Å A
34.7% 282-430
PDBe RCSB PDBj File
Loaded
PDB 6XRF
X-ray 2.56 Å C,F,I
14.0% 1-60
PDBe RCSB PDBj File
Loaded
AlphaFold PA0093
AlphaFold — — full sequence — Loaded
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