Protein profile

PA0113

protoheme IX farnesyltransferase

Genome: NC_002516.2

Gene: cyoE1 PA0113 Structure source: AlphaFold UniProt Q9I719
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Amino acids 304
Annotations 7
Features 43
PDB binders 0
Druggability 0.758

Overview

Basic information about this protein and its source genome.

Accession
PA0113
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cyoE1 PA0113
Status
annotated
Amino acids
304
Structure source
AlphaFold
EC
2.5.1.141
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008495 Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. GO:0048034 The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
38.217
Human E-value
2.7e-23
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.758
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008495 Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.
  • GO:0006783 The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
  • GO:0048034 The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle.
  • GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

43 records
Show feature table
Start End DB Term Name
280 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
278 298 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
246 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 283 Pfam PF01040 UbiA prenyltransferase family
29 283 InterPro IPR000537 UbiA prenyltransferase family
174 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
45 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
122 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 93 ProSitePatterns PS00943 UbiA prenyltransferase family signature.
71 93 InterPro IPR030470 UbiA prenyltransferase conserved site
50 74 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 296 NCBIfam TIGR01473 heme o synthase
14 296 InterPro IPR006369 Protohaem IX farnesyltransferase
195 222 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 297 Hamap MF_00154 Protoheme IX farnesyltransferase [cyoE].
12 297 InterPro IPR006369 Protohaem IX farnesyltransferase
75 94 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
124 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 148 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
218 240 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 118 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 123 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 74 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
241 245 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
169 173 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 291 CDD cd13957 PT_UbiA_Cox10
17 291 InterPro IPR006369 Protohaem IX farnesyltransferase
24 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
149 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
245 267 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
223 240 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 178 FunFam G3DSA:1.10.357.140:FF:000001 Protoheme IX farnesyltransferase
19 178 Gene3D G3DSA:1.10.357.140 UbiA prenyltransferase
19 178 InterPro IPR044878 UbiA prenyltransferase superfamily
149 168 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 295 PANTHER PTHR43448 PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL
14 295 InterPro IPR006369 Protohaem IX farnesyltransferase
178 197 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
299 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0113
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.686
7 0.57
3 0.281