Protein profile

PA0120

transcriptional regulator

Genome: NC_002516.2

Gene: PA0120 Structure source: AlphaFold UniProt Q9I712
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Amino acids 228
Annotations 3
Features 25
PDB binders 0
Druggability 0.846

Overview

Basic information about this protein and its source genome.

Accession
PA0120
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0120
Status
annotated
Amino acids
228
Structure source
AlphaFold
GO
GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.846
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
9 70 Pfam PF00392 Bacterial regulatory proteins, gntR family
9 70 InterPro IPR000524 Transcription regulator HTH, GntR
6 70 CDD cd07377 WHTH_GntR
6 70 InterPro IPR000524 Transcription regulator HTH, GntR
90 213 Pfam PF07729 FCD domain
90 213 InterPro IPR011711 GntR, C-terminal
90 214 SMART SM00895 FCD_2
90 214 InterPro IPR011711 GntR, C-terminal
4 218 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
85 219 Gene3D G3DSA:1.20.120.530 -
85 219 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
3 74 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
3 74 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 70 Gene3D G3DSA:1.10.10.10 -
1 70 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
5 73 ProSiteProfiles PS50949 GntR-type HTH domain profile.
5 73 InterPro IPR000524 Transcription regulator HTH, GntR
88 218 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
88 218 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
11 70 SMART SM00345 gntr3
11 70 InterPro IPR000524 Transcription regulator HTH, GntR
44 60 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
44 60 InterPro IPR000524 Transcription regulator HTH, GntR
30 44 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
30 44 InterPro IPR000524 Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0120
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.846
1 0.234