Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0121
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0121
Status: annotated
Amino acids: 244
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.73

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MVGFEARTQQGAALRPTSHFVYESIYTAILEKRLAPAAKLSKETLGQIFRVSNGTIQRALTRLAEDGAVVMPPKEVASVARPDERQARQVLDARLLVESEVVRQLPAGLDPAALAELRALVDEEQACLAARDSAGLIRLAGRFHLRLAELTENPLLQGFVRGLVARASLDIALNKGAVYTAEACAAQRALLDALEDGDSAAAAALMDAYLRGLFARMRFLPPPTTDLREAFGMKAPSGEKRRRA

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
89	212	SMART	SM00895	FCD_2
89	212	InterPro	IPR011711	GntR, C-terminal
16	83	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
16	83	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
18	71	Pfam	PF00392	Bacterial regulatory proteins, gntR family
18	71	InterPro	IPR000524	Transcription regulator HTH, GntR
83	219	Gene3D	G3DSA:1.20.120.530	-
83	219	InterPro	IPR008920	Transcription regulator FadR/GntR, C-terminal
87	217	SUPERFAMILY	SSF48008	GntR ligand-binding domain-like
87	217	InterPro	IPR008920	Transcription regulator FadR/GntR, C-terminal
15	82	ProSiteProfiles	PS50949	GntR-type HTH domain profile.
15	82	InterPro	IPR000524	Transcription regulator HTH, GntR
15	82	Gene3D	G3DSA:1.10.10.10	-
15	82	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
10	216	PANTHER	PTHR43537	TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
89	211	Pfam	PF07729	FCD domain
89	211	InterPro	IPR011711	GntR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0121	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.73
3				0.555

PA0121