Protein profile

PA0168

hypothetical protein

Genome: NC_002516.2

Gene: PA0168 Structure source: AlphaFold UniProt Q9I6W4
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Amino acids 196
Annotations 5
Features 15
PDB binders 1
Druggability 0.441

Overview

Basic information about this protein and its source genome.

Accession
PA0168
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0168
Status
annotated
Amino acids
196
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043168 Binding to an anion, a charged atom or group of atoms with a net negative charge. GO:0032561 Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. GO:0017111 Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. GO:0006446 Any process that modulates the frequency, rate or extent of translational initiation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.441
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0043168 Binding to an anion, a charged atom or group of atoms with a net negative charge.
  • GO:0032561 Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
  • GO:0017111 Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
  • GO:0006446 Any process that modulates the frequency, rate or extent of translational initiation.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
7 121 SUPERFAMILY SSF54211 Ribosomal protein S5 domain 2-like
7 121 InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
2 125 Gene3D G3DSA:3.30.230.30 -
2 125 InterPro IPR036956 Impact, N-terminal domain superfamily
71 100 ProSitePatterns PS00910 Uncharacterized protein family UPF0029 signature.
71 100 InterPro IPR020569 Uncharacterised protein family UPF0029, Impact, conserved site
4 141 PANTHER PTHR16301 IMPACT-RELATED
4 141 InterPro IPR023582 Impact family
133 188 Pfam PF09186 Domain of unknown function (DUF1949)
133 188 InterPro IPR015269 Uncharacterised domain UPF0029, Impact, C-terminal
126 191 Gene3D G3DSA:3.30.70.240 -
16 115 Pfam PF01205 Uncharacterized protein family UPF0029
16 115 InterPro IPR001498 Impact, N-terminal
127 195 SUPERFAMILY SSF54980 EF-G C-terminal domain-like
127 195 InterPro IPR035647 EF-G domain III/V-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0168
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.441

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

16 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
TLA
2CVE
Q5SJF5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.