Protein profile

PA0172

hypothetical protein

Genome: NC_002516.2

Gene: PA0172 Structure source: Experimental + AlphaFold UniProt Q9I6W0
Export view
Amino acids 663
Annotations 4
Features 29
PDB binders 0
Druggability 0.852

Overview

Basic information about this protein and its source genome.

Accession
PA0172
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0172
Status
annotated
Amino acids
663
Structure source
Experimental + AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872 Binding to a metal ion. GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.852
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0046872 Binding to a metal ion.
  • GO:0016791 Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
337 389 SMART SM00304 HAMP_11
337 389 InterPro IPR003660 HAMP domain
384 415 Coils Coil Coil
6 663 NCBIfam NF038263 biofilm regulation protein phosphatase SiaA
337 386 SUPERFAMILY SSF158472 HAMP domain-like
466 663 Pfam PF07228 Stage II sporulation protein E (SpoIIE)
466 663 InterPro IPR001932 PPM-type phosphatase-like domain
304 396 Gene3D G3DSA:6.10.340.10 -
337 386 Pfam PF00672 HAMP domain
337 386 InterPro IPR003660 HAMP domain
404 661 Gene3D G3DSA:3.60.40.10 -
404 661 InterPro IPR036457 PPM-type phosphatase-like domain superfamily
312 335 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
192 301 CDD cd18774 PDC2_HK_sensor
312 334 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
12 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
337 389 ProSiteProfiles PS50885 HAMP domain profile.
44 663 PANTHER PTHR43156 STAGE II SPORULATION PROTEIN E-RELATED
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
453 662 SMART SM00331 PP2C_SIG_2
453 662 InterPro IPR001932 PPM-type phosphatase-like domain
31 311 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
448 659 SUPERFAMILY SSF81606 PP2C-like
448 659 InterPro IPR036457 PPM-type phosphatase-like domain superfamily
350 383 CDD cd06225 HAMP
336 663 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6K4E
X-ray 2.09 Å A,B
41.9% 386-663
PDBe RCSB PDBj File
Viewing
AlphaFold PA0172
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.852
7 0.738
11 0.464

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.66 0.203
2 1.2 0.011