Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0175
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cheR2 PA0175
Status: annotated
Amino acids: 280
Structure source: AlphaFold

EC

2.1.1.80

GO

GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0008983 Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.463

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

2.1.1.80

Gene Ontology (GO)

6

GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus.
GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0008983 Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0032259 The process in which a methyl group is covalently attached to a molecule.
GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records

Show feature table

Start	End	DB	Term	Name
85	277	SUPERFAMILY	SSF53335	S-adenosyl-L-methionine-dependent methyltransferases
85	277	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
10	280	ProSiteProfiles	PS50123	CheR-type methyltransferase domain profile.
10	280	InterPro	IPR000780	MCP methyltransferase, CheR-type
114	255	CDD	cd02440	AdoMet_MTases
84	280	Gene3D	G3DSA:3.40.50.150	Vaccinia Virus protein VP39
84	280	InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
20	72	Pfam	PF03705	CheR methyltransferase, all-alpha domain
20	72	InterPro	IPR022641	Chemotaxis receptor methyltransferase CheR, N-terminal
21	274	PANTHER	PTHR24422	CHEMOTAXIS PROTEIN METHYLTRANSFERASE
220	234	PRINTS	PR00996	Glutamate methyltransferase family signature
220	234	InterPro	IPR000780	MCP methyltransferase, CheR-type
239	262	PRINTS	PR00996	Glutamate methyltransferase family signature
239	262	InterPro	IPR000780	MCP methyltransferase, CheR-type
148	164	PRINTS	PR00996	Glutamate methyltransferase family signature
148	164	InterPro	IPR000780	MCP methyltransferase, CheR-type
41	54	PRINTS	PR00996	Glutamate methyltransferase family signature
41	54	InterPro	IPR000780	MCP methyltransferase, CheR-type
78	90	PRINTS	PR00996	Glutamate methyltransferase family signature
78	90	InterPro	IPR000780	MCP methyltransferase, CheR-type
114	134	PRINTS	PR00996	Glutamate methyltransferase family signature
114	134	InterPro	IPR000780	MCP methyltransferase, CheR-type
3	280	PIRSF	PIRSF000410	CheR
3	280	InterPro	IPR026024	Chemotaxis protein methyltransferase CheR
19	280	SMART	SM00138	methyl_trans_3
19	280	InterPro	IPR000780	MCP methyltransferase, CheR-type
12	84	SUPERFAMILY	SSF47757	Chemotaxis receptor methyltransferase CheR, N-terminal domain
85	277	Pfam	PF01739	CheR methyltransferase, SAM binding domain
85	277	InterPro	IPR022642	MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal
10	83	Gene3D	G3DSA:1.10.155.10	-
10	83	InterPro	IPR036804	Chemotaxis receptor methyltransferase CheR, N-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0175	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.463
1				0.233

PA0175