Protein profile

PA0176

aerotaxis transducer Aer2

Genome: NC_002516.2

Gene: PA0176 tlpG mcpB aer-2 aer2 Structure source: Experimental + AlphaFold UniProt Q9I6V6
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Amino acids 679
Annotations 10
Features 41
PDB binders 0
Druggability 0.8

Overview

Basic information about this protein and its source genome.

Accession
PA0176
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0176 tlpG mcpB aer-2 aer2
Status
annotated
Amino acids
679
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042802 Binding to an identical protein or proteins. GO:0046872 Binding to a metal ion. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0009454 The directed movement of a motile cell or organism in response to environmental oxygen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.8
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042802 Binding to an identical protein or proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0009454 The directed movement of a motile cell or organism in response to environmental oxygen.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0052131 The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen.
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
173 221 Pfam PF13188 PAS domain
173 221 InterPro IPR000014 PAS domain
561 590 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
561 590 InterPro IPR004090 Chemotaxis methyl-accepting receptor
513 542 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
513 542 InterPro IPR004090 Chemotaxis methyl-accepting receptor
484 511 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
484 511 InterPro IPR004090 Chemotaxis methyl-accepting receptor
407 436 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
407 436 InterPro IPR004090 Chemotaxis methyl-accepting receptor
170 289 FunFam G3DSA:3.30.450.20:FF:000075 Methyl-accepting chemotaxis protein
170 289 Gene3D G3DSA:3.30.450.20 PAS domain
390 619 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
390 619 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
112 155 CDD cd17528 HAMP_III
411 636 FunFam G3DSA:1.10.287.950:FF:000002 Methyl-accepting chemotaxis protein
386 633 SMART SM00283 MA_2
386 633 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
446 601 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
446 601 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
333 385 ProSiteProfiles PS50885 HAMP domain profile.
333 385 InterPro IPR003660 HAMP domain
289 662 PANTHER PTHR43531 PROTEIN ICFG
336 635 Gene3D G3DSA:1.10.287.950 -
114 156 Pfam PF18575 HAMP N-terminal domain 3
114 156 InterPro IPR041395 HAMP N-terminal domain 3
171 213 ProSiteProfiles PS50112 PAS repeat profile.
171 213 InterPro IPR000014 PAS domain
1 156 Gene3D G3DSA:1.20.120.1530 -
41 68 Coils Coil Coil
590 617 Coils Coil Coil
413 604 CDD cd11386 MCP_signal
167 275 SUPERFAMILY SSF55785 PYP-like sensor domain (PAS domain)
167 275 InterPro IPR035965 PAS domain superfamily
409 429 Coils Coil Coil
353 634 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
644 679 MobiDBLite mobidb-lite consensus disorder prediction
11 55 CDD cd17529 HAMP_I
318 379 Pfam PF18947 HAMP domain
318 379 InterPro IPR003660 HAMP domain
1 156 FunFam G3DSA:1.20.120.1530:FF:000009 Aerotaxis transducer Aer2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3VOL
X-ray 2.40 Å A
31.2% 173-384
PDBe RCSB PDBj File
Viewing
PDB 4I3M
X-ray 1.95 Å A
25.3% 1-172
PDBe RCSB PDBj File
Loaded
PDB 3LNR
X-ray 2.64 Å A
25.3% 1-172
PDBe RCSB PDBj File
Loaded
PDB 4I44
X-ray 2.88 Å A
25.3% 1-172
PDBe RCSB PDBj File
Loaded
PDB 4HI4
X-ray 2.30 Å A,B,D,G
17.1% 174-289
PDBe RCSB PDBj File
Loaded
AlphaFold PA0176
AlphaFold — — full sequence — Loaded
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