Protein profile

PA0185

ABC transporter permease

Genome: NC_002516.2

Gene: PA0185 Structure source: AlphaFold UniProt Q9I6U8
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Amino acids 538
Annotations 4
Features 57
PDB binders 0
Druggability 0.93

Overview

Basic information about this protein and its source genome.

Accession
PA0185
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0185
Status
annotated
Amino acids
538
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042918 The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.93
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042918 The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

57 records
Show feature table
Start End DB Term Name
123 144 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
454 476 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
477 505 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
451 476 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
80 264 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
80 264 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
311 351 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
340 534 Gene3D G3DSA:1.10.3720.10 -
340 534 InterPro IPR035906 MetI-like superfamily
70 272 Gene3D G3DSA:1.10.3720.10 -
70 272 InterPro IPR035906 MetI-like superfamily
506 525 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
34 51 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 122 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
240 259 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 271 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
103 271 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
362 528 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
362 528 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
294 310 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
373 383 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
170 189 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
383 405 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
351 373 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
338 524 SUPERFAMILY SSF161098 MetI-like
338 524 InterPro IPR035906 MetI-like superfamily
190 211 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
405 409 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
84 258 CDD cd06261 TM_PBP2
84 258 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
145 149 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 281 PANTHER PTHR30151 ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
410 430 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
506 524 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
52 90 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
240 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
78 263 SUPERFAMILY SSF161098 MetI-like
78 263 InterPro IPR035906 MetI-like superfamily
212 239 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
150 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 271 FunFam G3DSA:1.10.3720.10:FF:000003 Aliphatic sulfonate ABC transporter permease
389 517 CDD cd06261 TM_PBP2
389 517 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 34 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
344 525 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
344 525 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
384 404 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
525 538 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
261 293 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
352 372 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
431 450 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0185
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.93
12 0.425
8 0.391
19 0.301