Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0197
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tonB2 PA0197
Status: annotated
Amino acids: 270
Structure source: AlphaFold

GO

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0098797 Any protein complex that is part of the plasma membrane. GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.866

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0098797 Any protein complex that is part of the plasma membrane.
GO:0031992 The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
191	269	Pfam	PF03544	Gram-negative bacterial TonB protein C-terminal
191	269	InterPro	IPR037682	TonB, C-terminal
1	51	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
80	136	MobiDBLite	mobidb-lite	consensus disorder prediction
130	140	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
130	140	InterPro	IPR003538	Gram-negative bacterial TonB protein
187	208	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
187	208	InterPro	IPR003538	Gram-negative bacterial TonB protein
208	226	PRINTS	PR01374	Gram-negative bacterial tonB protein signature
208	226	InterPro	IPR003538	Gram-negative bacterial TonB protein
52	70	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
71	270	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
144	178	MobiDBLite	mobidb-lite	consensus disorder prediction
193	270	NCBIfam	TIGR01352	TonB family C-terminal domain
193	270	InterPro	IPR006260	TonB/TolA, C-terminal
48	270	PANTHER	PTHR33446	PROTEIN TONB-RELATED
52	69	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
80	187	MobiDBLite	mobidb-lite	consensus disorder prediction
187	267	SUPERFAMILY	SSF74653	TolA/TonB C-terminal domain
147	270	Gene3D	G3DSA:3.30.1150.10	-
125	270	FunFam	G3DSA:3.30.1150.10:FF:000005	Protein TonB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0197	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.866

PA0197