Protein profile

PA0208

malonate decarboxylase subunit alpha

Genome: NC_002516.2

Gene: PA0208 mdcA Structure source: Experimental + AlphaFold UniProt Q9I6T0
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Amino acids 554
Annotations 1
Features 10
PDB binders 1
Druggability 0.616

Overview

Basic information about this protein and its source genome.

Accession
PA0208
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0208 mdcA
Status
annotated
Amino acids
554
Structure source
Experimental + AlphaFold
GO
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.616
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
39 244 Gene3D G3DSA:3.40.1080.10 -
10 554 Pfam PF16957 Malonate decarboxylase, alpha subunit, transporter
10 554 InterPro IPR005777 Acetyl-S-ACP:malonate ACP transferase
13 554 PANTHER PTHR43293 ACETATE COA-TRANSFERASE YDIF
11 554 NCBIfam TIGR01110 malonate decarboxylase subunit alpha
11 554 InterPro IPR005777 Acetyl-S-ACP:malonate ACP transferase
230 493 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
230 493 InterPro IPR037171 NagB/RpiA transferase-like
42 282 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
42 282 InterPro IPR037171 NagB/RpiA transferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5VIT
X-ray 2.20 Å A,I,P,V
100.0% 1-554
PDBe RCSB PDBj File
Viewing
PDB 5VJ1
X-ray 3.00 Å A,I
100.0% 1-554
PDBe RCSB PDBj File
Loaded
AlphaFold PA0208
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.616
4 0.438
2 0.383

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 32.92 0.945
2 5.4 0.256
3 3.41 0.123
4 1.11 0.008

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
MLI
5VIT 2.20 Å Open crystal
102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.