Protein profile

PA0209

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Genome: NC_002516.2

Gene: PA0209 mdcB Structure source: AlphaFold UniProt Q9I6S9

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Amino acids 293

Annotations 5

Features 12

PDB binders 0

Druggability 0.624

Overview

Basic information about this protein and its source genome.

Accession: PA0209
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0209 mdcB
Status: annotated
Amino acids: 293
Structure source: AlphaFold

2.4.2.52

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.624

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

2.4.2.52

Gene Ontology (GO)

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine.
GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.
GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
4	285	PANTHER	PTHR30201	TRIPHOSPHORIBOSYL-DEPHOSPHO-COA SYNTHASE
4	285	InterPro	IPR002736	Triphosphoribosyl-dephospho-CoA protein
1	293	Hamap	MF_01883	2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase [mdcB].
1	293	InterPro	IPR017555	Triphosphoribosyl-dephospho-CoA synthase
155	284	FunFam	G3DSA:1.10.4200.10:FF:000002	Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
20	279	Pfam	PF01874	ATP:dephospho-CoA triphosphoribosyl transferase
20	279	InterPro	IPR002736	Triphosphoribosyl-dephospho-CoA protein
153	284	Gene3D	G3DSA:1.10.4200.10	-
45	152	Gene3D	G3DSA:1.10.4200.10	-
45	151	FunFam	G3DSA:1.10.4200.10:FF:000003	Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase
18	282	NCBIfam	TIGR03132	triphosphoribosyl-dephospho-CoA synthase MdcB
18	282	InterPro	IPR017555	Triphosphoribosyl-dephospho-CoA synthase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0209	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.624