Protein profile

PA0212

malonate decarboxylase subunit gamma

Genome: NC_002516.2

Gene: PA0212 mdcE Structure source: Experimental + AlphaFold UniProt Q9I6S6
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Amino acids 268
Annotations 1
Features 6
PDB binders 0
Druggability 0.882

Overview

Basic information about this protein and its source genome.

Accession
PA0212
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0212 mdcE
Status
annotated
Amino acids
268
Structure source
Experimental + AlphaFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.882
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
19 215 Gene3D G3DSA:3.90.226.10 -
26 244 SUPERFAMILY SSF52096 ClpP/crotonase
26 244 InterPro IPR029045 ClpP/crotonase-like domain superfamily
9 268 NCBIfam TIGR03134 biotin-independent malonate decarboxylase subunit gamma
9 268 InterPro IPR009648 Biotin-dependent malonate decarboxylase, gamma subunit
11 268 Pfam PF06833 Malonate decarboxylase gamma subunit (MdcE)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5VIP
X-ray 1.86 Å A,C
100.0% 1-268
PDBe RCSB PDBj File
Viewing
PDB 5VIT
X-ray 2.20 Å E,M,T,Z
100.0% 1-268
PDBe RCSB PDBj File
Loaded
PDB 5VJ1
X-ray 3.00 Å E,M
100.0% 1-268
PDBe RCSB PDBj File
Loaded
AlphaFold PA0212
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.755
1 0.315

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.2 0.053