Protein profile

PA0213

phosphoribosyl-dephospho-CoA transferase

Genome: NC_002516.2

Gene: PA0213 mdcG Structure source: AlphaFold UniProt Q9I6S5
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Amino acids 230
Annotations 2
Features 8
PDB binders 0
Druggability 0.856

Overview

Basic information about this protein and its source genome.

Accession
PA0213
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0213 mdcG
Status
annotated
Amino acids
230
Structure source
AlphaFold
EC
2.7.7.66
GO
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.856
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
29 222 Pfam PF10620 Phosphoribosyl-dephospho-CoA transferase MdcG
29 222 InterPro IPR017557 Phosphoribosyl-dephospho-CoA transferase
26 227 Hamap MF_00650 Phosphoribosyl-dephospho-CoA transferase [mdcG].
26 227 InterPro IPR017557 Phosphoribosyl-dephospho-CoA transferase
1 29 MobiDBLite mobidb-lite consensus disorder prediction
15 29 MobiDBLite mobidb-lite consensus disorder prediction
29 221 NCBIfam TIGR03135 malonate decarboxylase holo-[acyl-carrier-protein] synthase
29 221 InterPro IPR017557 Phosphoribosyl-dephospho-CoA transferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0213
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.856
3 0.243
8 0.209