Protein profile

PA0229

dicarboxylic acid transporter PcaT

Genome: NC_002516.2

Gene: pcaT PA0229 Structure source: AlphaFold UniProt Q9I6Q9
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Amino acids 432
Annotations 5
Features 56
PDB binders 0
Druggability 0.899

Overview

Basic information about this protein and its source genome.

Accession
PA0229
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pcaT PA0229
Status
annotated
Amino acids
432
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015294 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.899
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015294 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

56 records
Show feature table
Start End DB Term Name
136 155 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
211 239 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
156 178 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
368 389 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 419 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
308 326 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 428 FunFam G3DSA:1.20.1250.20:FF:000095 Alpha-ketoglutarate permease
332 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
80 90 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
259 277 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
265 420 Pfam PF07690 Major Facilitator Superfamily
265 420 InterPro IPR011701 Major facilitator superfamily
156 179 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
327 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 430 PANTHER PTHR43528 ALPHA-KETOGLUTARATE PERMEASE
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
193 210 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 423 CDD cd17367 MFS_KgtP
420 432 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
119 136 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
191 210 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
10 217 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
10 217 InterPro IPR036259 MFS transporter superfamily
218 428 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
218 428 InterPro IPR036259 MFS transporter superfamily
357 367 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
180 190 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
91 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
277 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
129 154 ProSitePatterns PS00217 Sugar transport proteins signature 2.
129 154 InterPro IPR005829 Sugar transporter, conserved site
46 56 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 412 NCBIfam TIGR00883 metabolite/H+ symporter
26 412 InterPro IPR004736 MFS transporter, metabolite:H symporter
21 217 Pfam PF00083 Sugar (and other) transporter
21 217 InterPro IPR005828 Major facilitator, sugar transporter-like
240 262 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 45 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
240 258 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
113 117 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 135 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
368 390 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
306 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
390 400 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
278 296 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
401 419 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 424 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
19 424 InterPro IPR020846 Major facilitator superfamily domain
12 424 SUPERFAMILY SSF103473 MFS general substrate transporter
12 424 InterPro IPR036259 MFS transporter superfamily
297 307 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
57 79 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0229
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.899
17 0.263
16 0.255