Protein profile

PA0232

4-carboxymuconolactone decarboxylase

Genome: NC_002516.2

Gene: pcaC PA0232 Structure source: AlphaFold UniProt Q9I6Q6
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Amino acids 133
Annotations 3
Features 9
PDB binders 0
Druggability 0.667

Overview

Basic information about this protein and its source genome.

Accession
PA0232
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pcaC PA0232
Status
annotated
Amino acids
133
Structure source
AlphaFold
EC
4.1.1.44
GO
GO:0047575 Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2. GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.667
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDEKQRYEAGMQVRRAVLGAAHVERSLANLTPFNEEFQEMITRHAWGDIWTRPGLPRHTRSLVTIAMLIGMNRNEELKLHLRAAKNNGVSRDEIKEVIMQSAIYCGIPAANATFHLAESVWDELGVESQQASR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0047575 Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2.
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
4 127 SUPERFAMILY SSF69118 AhpD-like
4 127 InterPro IPR029032 AhpD-like
36 118 Pfam PF02627 Carboxymuconolactone decarboxylase family
36 118 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
3 124 NCBIfam TIGR02425 4-carboxymuconolactone decarboxylase
3 124 InterPro IPR012788 4-carboxymuconolactone decarboxylase
3 124 PANTHER PTHR33570 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN
4 125 Gene3D G3DSA:1.20.1290.10 -
4 125 InterPro IPR029032 AhpD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0232
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.667