Protein profile

PA0239

hypothetical protein

Genome: NC_002516.2

Gene: PA0239 Structure source: AlphaFold UniProt Q9I6P9
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Amino acids 292
Annotations 1
Features 38
PDB binders 0
Druggability 0.777

Overview

Basic information about this protein and its source genome.

Accession
PA0239
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0239
Status
annotated
Amino acids
292
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.777
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

38 records
Show feature table
Start End DB Term Name
234 244 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
187 208 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 14 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
188 210 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
149 153 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125 130 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 83 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 103 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
153 175 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
159 286 Pfam PF00892 EamA-like transporter family
159 286 InterPro IPR000620 EamA domain
16 148 Pfam PF00892 EamA-like transporter family
16 148 InterPro IPR000620 EamA domain
176 186 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
289 292 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
271 288 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
107 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
195 291 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
214 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
265 269 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
84 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
16 288 PANTHER PTHR22911 ACYL-MALONYL CONDENSING ENZYME-RELATED
209 213 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
245 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 267 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
53 152 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
102 106 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
214 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
270 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 148 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
154 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
107 124 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 64 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 39 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0239
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.777
4 0.685
2 0.527
11 0.291