Protein profile

PA0253

transcriptional regulator

Genome: NC_002516.2

Gene: PA0253 Structure source: AlphaFold UniProt Q9I6N6
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Amino acids 158
Annotations 4
Features 15
PDB binders 5
Druggability 0.861

Overview

Basic information about this protein and its source genome.

Accession
PA0253
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0253
Status
annotated
Amino acids
158
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.861
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
73 108 ProSitePatterns PS01117 MarR-type HTH domain signature.
73 108 InterPro IPR023187 Transcriptional regulator MarR-type, conserved site
44 100 Pfam PF01047 MarR family
44 100 InterPro IPR000835 MarR-type HTH domain
2 150 Gene3D G3DSA:1.10.10.10 -
2 150 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
34 137 SMART SM00347 marrlong4
34 137 InterPro IPR000835 MarR-type HTH domain
8 152 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
8 152 InterPro IPR036390 Winged helix DNA-binding domain superfamily
2 150 FunFam G3DSA:1.10.10.10:FF:001297 MarR family transcriptional regulator
14 148 ProSiteProfiles PS50995 MarR-type HTH domain profile.
14 148 InterPro IPR000835 MarR-type HTH domain
21 148 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
21 148 InterPro IPR039422 Transcription regulators MarR/SlyA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0253
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.861

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

55 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DHB
4RGX
Q7X0D9 154.1 Da LogP 0.80 TPSA 77.8 ✓ Ro5 Alert c1cc(c(cc1C(=O)O)O)O
FER
4RGU
Q7X0D9 194.2 Da LogP 1.50 TPSA 66.8 ✓ Ro5 ✓ Clean COc1cc(ccc1O)\C=C\C(=O)O
HC4
4RGR
Q7X0D9 164.2 Da LogP 1.49 TPSA 57.5 ✓ Ro5 ✓ Clean c1cc(ccc1/C=C/C(=O)O)O
SAL
1JGS
P27245 138.1 Da LogP 1.09 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc(c(c1)C(=O)O)O
V55
4RGS
Q7X0D9 152.1 Da LogP 1.21 TPSA 46.5 ✓ Ro5 ✓ Clean COc1cc(ccc1O)C=O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.