Protein profile

PA0259

hypothetical protein

Genome: NC_002516.2

Gene: PA0259 tla3 Structure source: Experimental + AlphaFold UniProt Q9I6N0
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Amino acids 480
Annotations 2
Features 5
PDB binders 0
Druggability 0.923

Overview

Basic information about this protein and its source genome.

Accession
PA0259
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0259 tla3
Status
annotated
Amino acids
480
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802 Binding to an identical protein or proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.923
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0042802 Binding to an identical protein or proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
413 466 MobiDBLite mobidb-lite consensus disorder prediction
252 417 Pfam PF11394 Protein of unknown function (DUF2875)
252 417 InterPro IPR021531 Protein of unknown function DUF2875
17 240 Pfam PF11394 Protein of unknown function (DUF2875)
17 240 InterPro IPR021531 Protein of unknown function DUF2875

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8YZ3
X-ray 1.80 Å A
100.0% 1-480
PDBe RCSB PDBj File
Viewing
AlphaFold PA0259
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.773
9 0.382

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.44 0.39
2 3.95 0.157
3 3.43 0.124
4 2.62 0.076
5 1.65 0.028